Microfluidic Technologies in Advancing Cancer Research

This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-...

Celý popis

Podrobná bibliografie
Hlavní autoři: Arjun Ajikumar, Kin Fong Lei
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2024-11-01
Edice:Micromachines
Témata:
On-line přístup:https://www.mdpi.com/2072-666X/15/12/1444
_version_ 1826916149257830400
author Arjun Ajikumar
Kin Fong Lei
author_facet Arjun Ajikumar
Kin Fong Lei
author_sort Arjun Ajikumar
collection DOAJ
description This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-based microfluidics allows precise manipulation of cells and three-dimensional microtissues, enabling high-throughput experiments that reveal insights into cancer cell migration, invasion, and drug resistance. Organ-on-chip systems replicate human organs to assess drug efficacy and toxicity, particularly in the liver, heart, kidney, gut, lung, and brain. Paper-based microfluidics offers an alternative approach to accomplish rapid diagnostics and cell- and tissue-based bioassays. Electrokinetic microfluidic chips offer precise control over cell positioning and behavior, facilitating drug screening and cellular studies. Immune response studies leverage real-time observation of interactions between immune and cancer cells, supporting the development of immunotherapies. These microfluidic advances are paving the way for personalized cancer treatments while addressing challenges of scalability, cost, and clinical integration.
first_indexed 2025-02-17T12:10:44Z
format Article
id doaj.art-a00456ea9fa94fb2b51a4824d546b46e
institution Directory Open Access Journal
issn 2072-666X
language English
last_indexed 2025-02-17T12:10:44Z
publishDate 2024-11-01
publisher MDPI AG
record_format Article
series Micromachines
spelling doaj.art-a00456ea9fa94fb2b51a4824d546b46e2024-12-27T14:40:41ZengMDPI AGMicromachines2072-666X2024-11-011512144410.3390/mi15121444Microfluidic Technologies in Advancing Cancer ResearchArjun Ajikumar0Kin Fong Lei1Department of Biomedical Engineering, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Biomedical Engineering, Chang Gung University, Taoyuan 33302, TaiwanThis review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-based microfluidics allows precise manipulation of cells and three-dimensional microtissues, enabling high-throughput experiments that reveal insights into cancer cell migration, invasion, and drug resistance. Organ-on-chip systems replicate human organs to assess drug efficacy and toxicity, particularly in the liver, heart, kidney, gut, lung, and brain. Paper-based microfluidics offers an alternative approach to accomplish rapid diagnostics and cell- and tissue-based bioassays. Electrokinetic microfluidic chips offer precise control over cell positioning and behavior, facilitating drug screening and cellular studies. Immune response studies leverage real-time observation of interactions between immune and cancer cells, supporting the development of immunotherapies. These microfluidic advances are paving the way for personalized cancer treatments while addressing challenges of scalability, cost, and clinical integration.https://www.mdpi.com/2072-666X/15/12/1444microfluidicscancer researchdroplet-based microfluidicsorgan-on-chippaper-based microfluidicselectrokinetics
spellingShingle Arjun Ajikumar
Kin Fong Lei
Microfluidic Technologies in Advancing Cancer Research
Micromachines
microfluidics
cancer research
droplet-based microfluidics
organ-on-chip
paper-based microfluidics
electrokinetics
title Microfluidic Technologies in Advancing Cancer Research
title_full Microfluidic Technologies in Advancing Cancer Research
title_fullStr Microfluidic Technologies in Advancing Cancer Research
title_full_unstemmed Microfluidic Technologies in Advancing Cancer Research
title_short Microfluidic Technologies in Advancing Cancer Research
title_sort microfluidic technologies in advancing cancer research
topic microfluidics
cancer research
droplet-based microfluidics
organ-on-chip
paper-based microfluidics
electrokinetics
url https://www.mdpi.com/2072-666X/15/12/1444
work_keys_str_mv AT arjunajikumar microfluidictechnologiesinadvancingcancerresearch
AT kinfonglei microfluidictechnologiesinadvancingcancerresearch