Microfluidic Technologies in Advancing Cancer Research
This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/15/12/1444 |
| _version_ | 1826916149257830400 |
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| author | Arjun Ajikumar Kin Fong Lei |
| author_facet | Arjun Ajikumar Kin Fong Lei |
| author_sort | Arjun Ajikumar |
| collection | DOAJ |
| description | This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-based microfluidics allows precise manipulation of cells and three-dimensional microtissues, enabling high-throughput experiments that reveal insights into cancer cell migration, invasion, and drug resistance. Organ-on-chip systems replicate human organs to assess drug efficacy and toxicity, particularly in the liver, heart, kidney, gut, lung, and brain. Paper-based microfluidics offers an alternative approach to accomplish rapid diagnostics and cell- and tissue-based bioassays. Electrokinetic microfluidic chips offer precise control over cell positioning and behavior, facilitating drug screening and cellular studies. Immune response studies leverage real-time observation of interactions between immune and cancer cells, supporting the development of immunotherapies. These microfluidic advances are paving the way for personalized cancer treatments while addressing challenges of scalability, cost, and clinical integration. |
| first_indexed | 2025-02-17T12:10:44Z |
| format | Article |
| id | doaj.art-a00456ea9fa94fb2b51a4824d546b46e |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2025-02-17T12:10:44Z |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-a00456ea9fa94fb2b51a4824d546b46e2024-12-27T14:40:41ZengMDPI AGMicromachines2072-666X2024-11-011512144410.3390/mi15121444Microfluidic Technologies in Advancing Cancer ResearchArjun Ajikumar0Kin Fong Lei1Department of Biomedical Engineering, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Biomedical Engineering, Chang Gung University, Taoyuan 33302, TaiwanThis review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-based microfluidics allows precise manipulation of cells and three-dimensional microtissues, enabling high-throughput experiments that reveal insights into cancer cell migration, invasion, and drug resistance. Organ-on-chip systems replicate human organs to assess drug efficacy and toxicity, particularly in the liver, heart, kidney, gut, lung, and brain. Paper-based microfluidics offers an alternative approach to accomplish rapid diagnostics and cell- and tissue-based bioassays. Electrokinetic microfluidic chips offer precise control over cell positioning and behavior, facilitating drug screening and cellular studies. Immune response studies leverage real-time observation of interactions between immune and cancer cells, supporting the development of immunotherapies. These microfluidic advances are paving the way for personalized cancer treatments while addressing challenges of scalability, cost, and clinical integration.https://www.mdpi.com/2072-666X/15/12/1444microfluidicscancer researchdroplet-based microfluidicsorgan-on-chippaper-based microfluidicselectrokinetics |
| spellingShingle | Arjun Ajikumar Kin Fong Lei Microfluidic Technologies in Advancing Cancer Research Micromachines microfluidics cancer research droplet-based microfluidics organ-on-chip paper-based microfluidics electrokinetics |
| title | Microfluidic Technologies in Advancing Cancer Research |
| title_full | Microfluidic Technologies in Advancing Cancer Research |
| title_fullStr | Microfluidic Technologies in Advancing Cancer Research |
| title_full_unstemmed | Microfluidic Technologies in Advancing Cancer Research |
| title_short | Microfluidic Technologies in Advancing Cancer Research |
| title_sort | microfluidic technologies in advancing cancer research |
| topic | microfluidics cancer research droplet-based microfluidics organ-on-chip paper-based microfluidics electrokinetics |
| url | https://www.mdpi.com/2072-666X/15/12/1444 |
| work_keys_str_mv | AT arjunajikumar microfluidictechnologiesinadvancingcancerresearch AT kinfonglei microfluidictechnologiesinadvancingcancerresearch |