Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential
Immunotherapy approaches have advanced rapidly in recent years. While the greatest therapeutic advances so far have been achieved with T cell therapies such as immune checkpoint blockade and CAR-T, recent advances in NK cell therapy have highlighted the therapeutic potential of these cells. Chronic...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/23/5787 |
| _version_ | 1797463563469586432 |
|---|---|
| author | Max Yano John C. Byrd Natarajan Muthusamy |
| author_facet | Max Yano John C. Byrd Natarajan Muthusamy |
| author_sort | Max Yano |
| collection | DOAJ |
| description | Immunotherapy approaches have advanced rapidly in recent years. While the greatest therapeutic advances so far have been achieved with T cell therapies such as immune checkpoint blockade and CAR-T, recent advances in NK cell therapy have highlighted the therapeutic potential of these cells. Chronic lymphocytic leukemia (CLL), the most prevalent form of leukemia in Western countries, is a very immunosuppressive disease but still shows significant potential as a target of immunotherapy, including NK-based therapies. In addition to their antileukemia potential, NK cells are important immune effectors in the response to infections, which represent a major clinical concern for CLL patients. Here, we review the interactions between NK cells and CLL, describing functional changes and mechanisms of CLL-induced NK suppression, interactions with current therapeutic options, and the potential for therapeutic benefit using NK cell therapies. |
| first_indexed | 2024-03-09T17:52:31Z |
| format | Article |
| id | doaj.art-a0048094ecef491286d213f90b9a74bd |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:52:31Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a0048094ecef491286d213f90b9a74bd2023-11-24T10:38:36ZengMDPI AGCancers2072-66942022-11-011423578710.3390/cancers14235787Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic PotentialMax Yano0John C. Byrd1Natarajan Muthusamy2Medical Science Training Program, The Ohio State University College of Medicine, Columbus, OH 43210, USADepartment of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USADivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USAImmunotherapy approaches have advanced rapidly in recent years. While the greatest therapeutic advances so far have been achieved with T cell therapies such as immune checkpoint blockade and CAR-T, recent advances in NK cell therapy have highlighted the therapeutic potential of these cells. Chronic lymphocytic leukemia (CLL), the most prevalent form of leukemia in Western countries, is a very immunosuppressive disease but still shows significant potential as a target of immunotherapy, including NK-based therapies. In addition to their antileukemia potential, NK cells are important immune effectors in the response to infections, which represent a major clinical concern for CLL patients. Here, we review the interactions between NK cells and CLL, describing functional changes and mechanisms of CLL-induced NK suppression, interactions with current therapeutic options, and the potential for therapeutic benefit using NK cell therapies.https://www.mdpi.com/2072-6694/14/23/5787cancerleukemiaCLLchronic lymphocytic leukemiaNK cellnatural killer cell |
| spellingShingle | Max Yano John C. Byrd Natarajan Muthusamy Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential Cancers cancer leukemia CLL chronic lymphocytic leukemia NK cell natural killer cell |
| title | Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential |
| title_full | Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential |
| title_fullStr | Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential |
| title_full_unstemmed | Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential |
| title_short | Natural Killer Cells in Chronic Lymphocytic Leukemia: Functional Impairment and Therapeutic Potential |
| title_sort | natural killer cells in chronic lymphocytic leukemia functional impairment and therapeutic potential |
| topic | cancer leukemia CLL chronic lymphocytic leukemia NK cell natural killer cell |
| url | https://www.mdpi.com/2072-6694/14/23/5787 |
| work_keys_str_mv | AT maxyano naturalkillercellsinchroniclymphocyticleukemiafunctionalimpairmentandtherapeuticpotential AT johncbyrd naturalkillercellsinchroniclymphocyticleukemiafunctionalimpairmentandtherapeuticpotential AT natarajanmuthusamy naturalkillercellsinchroniclymphocyticleukemiafunctionalimpairmentandtherapeuticpotential |