Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk Abnormalities
Jie Pan,1 Qiuyan Li,1 Yan Sun,1 Yingying Gu,1 Yijie Ding,1 Nengzhi Pang,1 Yujia Zhou,1 Lei Pei,1 Mengqi Gao,1 Sixi Ma,1 Ying Xiao,1 Feilong Wu,1 De Hu,1 Yu-Ming Chen,2 Lili Yang1 1Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun...
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Dove Medical Press
2023-01-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/increased-serum-adipsin-correlates-with-mafld-and-metabolic-risk-abnor-peer-reviewed-fulltext-article-DMSO |
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| author | Pan J Li Q Sun Y Gu Y Ding Y Pang N Zhou Y Pei L Gao M Ma S Xiao Y Wu F Hu D Chen YM Yang L |
| author_facet | Pan J Li Q Sun Y Gu Y Ding Y Pang N Zhou Y Pei L Gao M Ma S Xiao Y Wu F Hu D Chen YM Yang L |
| author_sort | Pan J |
| collection | DOAJ |
| description | Jie Pan,1 Qiuyan Li,1 Yan Sun,1 Yingying Gu,1 Yijie Ding,1 Nengzhi Pang,1 Yujia Zhou,1 Lei Pei,1 Mengqi Gao,1 Sixi Ma,1 Ying Xiao,1 Feilong Wu,1 De Hu,1 Yu-Ming Chen,2 Lili Yang1 1Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Lili Yang, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74, Zhongshan Road 2, Yuexiu District, Guangzhou, Guangdong, 510080, People’s Republic of China, Tel +86-20-87330625, Email yangll7@mail.sysu.edu.cnPurpose: A panel of international experts proposed a new definition of fatty liver in 2020, namely metabolic dysfunction-associated fatty liver disease (MAFLD). As an adipokine, adipsin is closely related to metabolic-related diseases. In this study, we aimed to evaluate the relationship among MAFLD, serum adipsin, and metabolic risk abnormalities.Methods: Our study was a cross-sectional study based on the first follow-up of the Guangzhou Nutrition and Health Study (GNHS). A total of 908 patients with hepatic steatosis were involved in our study. Detailed data of patients were collected based upon questionnaire information, physical examination, and blood biochemical test.Results: Among the 908 patients, 789 patients were diagnosed with MAFLD. The levels of serum adipsin in the MAFLD group and non-MAFLD group were (3543.00 (3187.94– 3972.50) ng/mL) and (3095.33 (2778.71– 3354.77) ng/mL) (P < 0.001), respectively. After adjusting for potential confounders, adipsin levels were found to be associated with MAFLD. The OR was 3.46 (95% CI: 1.57– 7.64) for adipsin when comparing subjects in the highest tertile with those in the lowest tertile. With the increase in the number of metabolic risk abnormalities, both the levels of serum adipsin and the proportion of moderate to severe fatty liver increased (all p-trend < 0.001).Conclusion: Increased serum adipsin correlates with MAFLD. Both adipsin levels as well as fatty liver severity increase with higher numbers of metabolic risk abnormalities.Keywords: metabolic dysfunction-associated fatty liver disease, adipsin, metabolic risk abnormalities, hepatic steatosis |
| first_indexed | 2024-04-10T20:42:55Z |
| format | Article |
| id | doaj.art-a007a7b102854ce9b3b7472f1c56be62 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T20:42:55Z |
| publishDate | 2023-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-a007a7b102854ce9b3b7472f1c56be622023-01-24T18:10:57ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-01-01Volume 1618720081177Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk AbnormalitiesPan JLi QSun YGu YDing YPang NZhou YPei LGao MMa SXiao YWu FHu DChen YMYang LJie Pan,1 Qiuyan Li,1 Yan Sun,1 Yingying Gu,1 Yijie Ding,1 Nengzhi Pang,1 Yujia Zhou,1 Lei Pei,1 Mengqi Gao,1 Sixi Ma,1 Ying Xiao,1 Feilong Wu,1 De Hu,1 Yu-Ming Chen,2 Lili Yang1 1Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Lili Yang, Department of Nutrition, School of Public Health, Sun Yat-sen University, No. 74, Zhongshan Road 2, Yuexiu District, Guangzhou, Guangdong, 510080, People’s Republic of China, Tel +86-20-87330625, Email yangll7@mail.sysu.edu.cnPurpose: A panel of international experts proposed a new definition of fatty liver in 2020, namely metabolic dysfunction-associated fatty liver disease (MAFLD). As an adipokine, adipsin is closely related to metabolic-related diseases. In this study, we aimed to evaluate the relationship among MAFLD, serum adipsin, and metabolic risk abnormalities.Methods: Our study was a cross-sectional study based on the first follow-up of the Guangzhou Nutrition and Health Study (GNHS). A total of 908 patients with hepatic steatosis were involved in our study. Detailed data of patients were collected based upon questionnaire information, physical examination, and blood biochemical test.Results: Among the 908 patients, 789 patients were diagnosed with MAFLD. The levels of serum adipsin in the MAFLD group and non-MAFLD group were (3543.00 (3187.94– 3972.50) ng/mL) and (3095.33 (2778.71– 3354.77) ng/mL) (P < 0.001), respectively. After adjusting for potential confounders, adipsin levels were found to be associated with MAFLD. The OR was 3.46 (95% CI: 1.57– 7.64) for adipsin when comparing subjects in the highest tertile with those in the lowest tertile. With the increase in the number of metabolic risk abnormalities, both the levels of serum adipsin and the proportion of moderate to severe fatty liver increased (all p-trend < 0.001).Conclusion: Increased serum adipsin correlates with MAFLD. Both adipsin levels as well as fatty liver severity increase with higher numbers of metabolic risk abnormalities.Keywords: metabolic dysfunction-associated fatty liver disease, adipsin, metabolic risk abnormalities, hepatic steatosishttps://www.dovepress.com/increased-serum-adipsin-correlates-with-mafld-and-metabolic-risk-abnor-peer-reviewed-fulltext-article-DMSOmetabolic dysfunction-associated fatty liver diseaseadipsinmetabolic risk abnormalitieshepatic steatosis |
| spellingShingle | Pan J Li Q Sun Y Gu Y Ding Y Pang N Zhou Y Pei L Gao M Ma S Xiao Y Wu F Hu D Chen YM Yang L Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk Abnormalities Diabetes, Metabolic Syndrome and Obesity metabolic dysfunction-associated fatty liver disease adipsin metabolic risk abnormalities hepatic steatosis |
| title | Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk Abnormalities |
| title_full | Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk Abnormalities |
| title_fullStr | Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk Abnormalities |
| title_full_unstemmed | Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk Abnormalities |
| title_short | Increased Serum Adipsin Correlates with MAFLD and Metabolic Risk Abnormalities |
| title_sort | increased serum adipsin correlates with mafld and metabolic risk abnormalities |
| topic | metabolic dysfunction-associated fatty liver disease adipsin metabolic risk abnormalities hepatic steatosis |
| url | https://www.dovepress.com/increased-serum-adipsin-correlates-with-mafld-and-metabolic-risk-abnor-peer-reviewed-fulltext-article-DMSO |
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