Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus
Abstract Aims/Introduction Vaspin is linked to obesity and its metabolic abnormalities. However, the role of vaspin serum levels in diabetic retinopathy (DR) is unknown. In the present study, we investigated the association between serum levels of vaspin and both DR and vision‐threatening DR. Materi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-04-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13385 |
| _version_ | 1830373769786425344 |
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| author | Hong‐Wei Yang Yong‐gang Huang Chun‐liu Gai Guang‐rui Chai Shufang Lee |
| author_facet | Hong‐Wei Yang Yong‐gang Huang Chun‐liu Gai Guang‐rui Chai Shufang Lee |
| author_sort | Hong‐Wei Yang |
| collection | DOAJ |
| description | Abstract Aims/Introduction Vaspin is linked to obesity and its metabolic abnormalities. However, the role of vaspin serum levels in diabetic retinopathy (DR) is unknown. In the present study, we investigated the association between serum levels of vaspin and both DR and vision‐threatening DR. Materials and Methods This was a cross‐sectional single‐center observational study from December 2018 to September 2019. We evaluated circulating serum levels of vaspin in 372 participants with type 2 diabetes. DR was screened through detailed ocular examination. DR patients were also divided two groups: vision‐threatening DR and non‐vision‐threatening DR. The relationship between vaspin and DR was investigated by univariate and multivariate logistic regression analyses, and the results are shown as odds ratios with 95% confidence intervals. Results The vaspin serum levels of 372 patients were obtained, with a median value of 1.50 ng/mL (interquartile range 0.94–2.18 ng/mL). The median age of those patients was 53 years (interquartile range 44–62 years), and 44.4% were women. Patients with DR and VDTR had significantly increased vaspin serum levels (P < 0.001 andP < 0.001). A multivariable regression model found that patients with high levels of vaspin were approximately 1.85‐fold (odds ratio for per unit increase 1.85, 95% confidence interval 1.43–2.55; P < 0.001) more likely to experience DR, and 3.76‐fold (odds ratio for per unit increase 3.76, 95% confidence interval 2.05–6.55; P < 0.001) more likely to experience VTDR. The predictive value of vaspin was stronger in women than in men. Conclusion Higher vaspin serum levels were associated with an increased risk of DR and VDTR in patients with type 2 diabetes, which showed that vaspin is an important indicator factor for DR. |
| first_indexed | 2024-12-20T07:24:38Z |
| format | Article |
| id | doaj.art-a0094db3b7764b59b0af7aa4f414ac67 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-20T07:24:38Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-a0094db3b7764b59b0af7aa4f414ac672022-12-21T19:48:34ZengWileyJournal of Diabetes Investigation2040-11162040-11242021-04-0112456657310.1111/jdi.13385Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitusHong‐Wei Yang0Yong‐gang Huang1Chun‐liu Gai2Guang‐rui Chai3Shufang Lee4Department of Ophthalmology Shengjing Hospital of China Medical University Shenyang ChinaSchool of Mechanical Engineering and Automation Northeastern UniversityShenyang ChinaDepartment of Ophthalmology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Ophthalmology Shengjing Hospital of China Medical University Shenyang ChinaDepartment of Ophthalmology Shengjing Hospital of China Medical University Shenyang ChinaAbstract Aims/Introduction Vaspin is linked to obesity and its metabolic abnormalities. However, the role of vaspin serum levels in diabetic retinopathy (DR) is unknown. In the present study, we investigated the association between serum levels of vaspin and both DR and vision‐threatening DR. Materials and Methods This was a cross‐sectional single‐center observational study from December 2018 to September 2019. We evaluated circulating serum levels of vaspin in 372 participants with type 2 diabetes. DR was screened through detailed ocular examination. DR patients were also divided two groups: vision‐threatening DR and non‐vision‐threatening DR. The relationship between vaspin and DR was investigated by univariate and multivariate logistic regression analyses, and the results are shown as odds ratios with 95% confidence intervals. Results The vaspin serum levels of 372 patients were obtained, with a median value of 1.50 ng/mL (interquartile range 0.94–2.18 ng/mL). The median age of those patients was 53 years (interquartile range 44–62 years), and 44.4% were women. Patients with DR and VDTR had significantly increased vaspin serum levels (P < 0.001 andP < 0.001). A multivariable regression model found that patients with high levels of vaspin were approximately 1.85‐fold (odds ratio for per unit increase 1.85, 95% confidence interval 1.43–2.55; P < 0.001) more likely to experience DR, and 3.76‐fold (odds ratio for per unit increase 3.76, 95% confidence interval 2.05–6.55; P < 0.001) more likely to experience VTDR. The predictive value of vaspin was stronger in women than in men. Conclusion Higher vaspin serum levels were associated with an increased risk of DR and VDTR in patients with type 2 diabetes, which showed that vaspin is an important indicator factor for DR.https://doi.org/10.1111/jdi.13385DiabetesDiabetic retinopathyVaspin |
| spellingShingle | Hong‐Wei Yang Yong‐gang Huang Chun‐liu Gai Guang‐rui Chai Shufang Lee Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus Journal of Diabetes Investigation Diabetes Diabetic retinopathy Vaspin |
| title | Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
| title_full | Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
| title_fullStr | Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
| title_short | Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
| title_sort | serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
| topic | Diabetes Diabetic retinopathy Vaspin |
| url | https://doi.org/10.1111/jdi.13385 |
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