Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study
Cardiovascular risk factors such as high glucose, LDL-cholesterol, blood pressure, and impaired kidney function are particularly frequent in old-aged individuals. However, population-based data on the extent of cardiovascular risk factor control in the old-aged population is limited. AugUR is a coho...
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/6/2102 |
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| author | Ferdinand J. Donhauser Martina E. Zimmermann Anna B. Steinkirchner Simon Wiegrebe Alexander Dietl Caroline Brandl Ralph Burkhardt André Gessner Frank Schweda Tobias Bergler Elke Schäffner Carsten A. Böger Florian Kronenberg Andreas Luchner Klaus J. Stark Iris M. Heid |
| author_facet | Ferdinand J. Donhauser Martina E. Zimmermann Anna B. Steinkirchner Simon Wiegrebe Alexander Dietl Caroline Brandl Ralph Burkhardt André Gessner Frank Schweda Tobias Bergler Elke Schäffner Carsten A. Böger Florian Kronenberg Andreas Luchner Klaus J. Stark Iris M. Heid |
| author_sort | Ferdinand J. Donhauser |
| collection | DOAJ |
| description | Cardiovascular risk factors such as high glucose, LDL-cholesterol, blood pressure, and impaired kidney function are particularly frequent in old-aged individuals. However, population-based data on the extent of cardiovascular risk factor control in the old-aged population is limited. AugUR is a cohort of the mobile “70+”-year-old population of/near Regensburg, recruited via population registries. We conducted cross-sectional analyses assessing the proportion of AugUR participants with LDL-cholesterol, HbA1c, or blood pressure beyond recommended levels and their association with impaired creatinine- and cystatin-based estimated glomerular filtration rate (eGFR, <60 mL/min/1.73 m<sup>2</sup>) or urine albumin–creatinine ratio (UACR, ≥30 mg/g). Among 2215 AugUR participants, 74.7% were taking lipid-, glucose-, blood-pressure-lowering, or diuretic medication. High LDL-cholesterol at ≥116 mg/dL was observed for 76.1% (51.1% among those with prior cardiovascular events). We found HbA1c ≥ 7.0% for 6.3%, and high or low systolic blood pressure for 6.8% or 26.5%, respectively (≥160, <120 mmHg). Logistic regression revealed (i) high HbA1c levels associated with increased risk for impaired kidney function among those untreated, (ii) high blood pressure with increased UACR, and (iii) low blood pressure with impaired eGFR, which was confined to individuals taking diuretics. Our results provide important insights into cardiovascular risk factor control in individuals aged 70–95 years, which are understudied in most population-based studies. |
| first_indexed | 2024-03-11T06:23:16Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:23:16Z |
| publishDate | 2023-03-01 |
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| spelling | doaj.art-a0098361bf4c4d5ea39e4286dd5e2c7d2023-11-17T11:48:07ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126210210.3390/jcm12062102Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR StudyFerdinand J. Donhauser0Martina E. Zimmermann1Anna B. Steinkirchner2Simon Wiegrebe3Alexander Dietl4Caroline Brandl5Ralph Burkhardt6André Gessner7Frank Schweda8Tobias Bergler9Elke Schäffner10Carsten A. Böger11Florian Kronenberg12Andreas Luchner13Klaus J. Stark14Iris M. Heid15Department of Genetic Epidemiology, University of Regensburg, 93053 Regensburg, GermanyDepartment of Genetic Epidemiology, University of Regensburg, 93053 Regensburg, GermanyDepartment of Genetic Epidemiology, University of Regensburg, 93053 Regensburg, GermanyDepartment of Genetic Epidemiology, University of Regensburg, 93053 Regensburg, GermanyDepartment of Internal Medicine II, University Hospital Regensburg, 93053 Regensburg, GermanyDepartment of Genetic Epidemiology, University of Regensburg, 93053 Regensburg, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, 93053 Regensburg, GermanyInstitute of Clinical Microbiology and Hygiene, University Hospital Regensburg, 93053 Regensburg, GermanyInstitute of Physiology, University of Regensburg, 93053 Regensburg, GermanyDepartment of Nephrology, University Hospital Regensburg, 93053 Regensburg, GermanyInstitute of Public Health, Charité Universitätsmedizin Berlin, 10117 Berlin, GermanyDepartment of Nephrology, University Hospital Regensburg, 93053 Regensburg, GermanyInstitute of Genetic Epidemiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Cardiology, Hospital Barmherzige Brüder Regensburg, 93049 Regensburg, GermanyDepartment of Genetic Epidemiology, University of Regensburg, 93053 Regensburg, GermanyDepartment of Genetic Epidemiology, University of Regensburg, 93053 Regensburg, GermanyCardiovascular risk factors such as high glucose, LDL-cholesterol, blood pressure, and impaired kidney function are particularly frequent in old-aged individuals. However, population-based data on the extent of cardiovascular risk factor control in the old-aged population is limited. AugUR is a cohort of the mobile “70+”-year-old population of/near Regensburg, recruited via population registries. We conducted cross-sectional analyses assessing the proportion of AugUR participants with LDL-cholesterol, HbA1c, or blood pressure beyond recommended levels and their association with impaired creatinine- and cystatin-based estimated glomerular filtration rate (eGFR, <60 mL/min/1.73 m<sup>2</sup>) or urine albumin–creatinine ratio (UACR, ≥30 mg/g). Among 2215 AugUR participants, 74.7% were taking lipid-, glucose-, blood-pressure-lowering, or diuretic medication. High LDL-cholesterol at ≥116 mg/dL was observed for 76.1% (51.1% among those with prior cardiovascular events). We found HbA1c ≥ 7.0% for 6.3%, and high or low systolic blood pressure for 6.8% or 26.5%, respectively (≥160, <120 mmHg). Logistic regression revealed (i) high HbA1c levels associated with increased risk for impaired kidney function among those untreated, (ii) high blood pressure with increased UACR, and (iii) low blood pressure with impaired eGFR, which was confined to individuals taking diuretics. Our results provide important insights into cardiovascular risk factor control in individuals aged 70–95 years, which are understudied in most population-based studies.https://www.mdpi.com/2077-0383/12/6/2102LDL-cholesterolHbA1cblood pressureestimated glomerular filtration rateurine albumin to creatinine ratioelderly population |
| spellingShingle | Ferdinand J. Donhauser Martina E. Zimmermann Anna B. Steinkirchner Simon Wiegrebe Alexander Dietl Caroline Brandl Ralph Burkhardt André Gessner Frank Schweda Tobias Bergler Elke Schäffner Carsten A. Böger Florian Kronenberg Andreas Luchner Klaus J. Stark Iris M. Heid Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study Journal of Clinical Medicine LDL-cholesterol HbA1c blood pressure estimated glomerular filtration rate urine albumin to creatinine ratio elderly population |
| title | Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study |
| title_full | Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study |
| title_fullStr | Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study |
| title_full_unstemmed | Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study |
| title_short | Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study |
| title_sort | cardiovascular risk factor control in 70 to 95 year old individuals cross sectional results from the population based augur study |
| topic | LDL-cholesterol HbA1c blood pressure estimated glomerular filtration rate urine albumin to creatinine ratio elderly population |
| url | https://www.mdpi.com/2077-0383/12/6/2102 |
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