Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound Treatment
Abstract Introduction Given the new ideas on wound care offered by the eCASH (early Comfort using Analgesia, minimal Sedatives, and maximal Humane care) and the substantial differences in clinical treatment between acute and chronic wounds, we aimed to investigate the effect of comfort therapy under...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Adis, Springer Healthcare
2022-12-01
|
| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13555-022-00852-5 |
| _version_ | 1797865551753641984 |
|---|---|
| author | Shuting Shi Jiayu Wei Guozhong Lyu Xiaohui Zhong Minlie Yang Lihong Zhu |
| author_facet | Shuting Shi Jiayu Wei Guozhong Lyu Xiaohui Zhong Minlie Yang Lihong Zhu |
| author_sort | Shuting Shi |
| collection | DOAJ |
| description | Abstract Introduction Given the new ideas on wound care offered by the eCASH (early Comfort using Analgesia, minimal Sedatives, and maximal Humane care) and the substantial differences in clinical treatment between acute and chronic wounds, we aimed to investigate the effect of comfort therapy under the eCASH concept on analgesic sedation and accelerated wound healing in patients with acute or chronic wounds. Methods This randomized clinical study was conducted in two parts: acute wounds and chronic wounds. Patients with acute wounds were allocated into the acute wound control group (AWCG) and the acute wound experimental group (AWEG). Patients with chronic wounds were allocated into the chronic wound control group (CWCG) and two experimental groups, in which they received intermittent negative pressure therapy (IPTEG) and continuous negative pressure therapy (CPTEG). On the basis of the standard treatment for patients in the control group, eCASH therapy was used in the experimental groups. In addition, pain intensity and procedural anxiety were evaluated using the visual analogue score (VAS) and the Hamilton Anxiety Scale (HAM-A). In addition, clinical effects were assessed on the basis of the size of the surface area, rate of healing, and concentration of pro-inflammatory factors (IL-1, IL-6, TNF-α) and growth factors (VEGF, bFGF, TGF-β1). Results Compared with the control group, the VAS score and HAM-A score in the experimental groups were significantly decreased after intervention (P < 0.05). After intervention, the levels of IL-1β, IL-6, and TNF-α in AWEG, IPTEG, and CPTEG were significantly lower than those in AWCG. In addition, the levels of VEGF, bFGF, and TGF-β1 in IPTEG and CPTEG were significantly higher than those in CWCG (P < 0.05). Conclusion These results indicated that comfort therapy under the eCASH concept has a significant effect on ameliorating the pain and anxiety of patients, reducing the inflammatory reaction during the period of wound healing in the treatment of acute and chronic wounds. Clinical Trial Registry The trial has been registered in the Chinese Clinical Trial Registry (ChiCTR2200057981). |
| first_indexed | 2024-04-09T23:09:56Z |
| format | Article |
| id | doaj.art-a00ad858045a45e587f33e8bb963b76f |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-04-09T23:09:56Z |
| publishDate | 2022-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-a00ad858045a45e587f33e8bb963b76f2023-03-22T10:28:29ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722022-12-0113129931410.1007/s13555-022-00852-5Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound TreatmentShuting Shi0Jiayu Wei1Guozhong Lyu2Xiaohui Zhong3Minlie Yang4Lihong Zhu5Wuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityAbstract Introduction Given the new ideas on wound care offered by the eCASH (early Comfort using Analgesia, minimal Sedatives, and maximal Humane care) and the substantial differences in clinical treatment between acute and chronic wounds, we aimed to investigate the effect of comfort therapy under the eCASH concept on analgesic sedation and accelerated wound healing in patients with acute or chronic wounds. Methods This randomized clinical study was conducted in two parts: acute wounds and chronic wounds. Patients with acute wounds were allocated into the acute wound control group (AWCG) and the acute wound experimental group (AWEG). Patients with chronic wounds were allocated into the chronic wound control group (CWCG) and two experimental groups, in which they received intermittent negative pressure therapy (IPTEG) and continuous negative pressure therapy (CPTEG). On the basis of the standard treatment for patients in the control group, eCASH therapy was used in the experimental groups. In addition, pain intensity and procedural anxiety were evaluated using the visual analogue score (VAS) and the Hamilton Anxiety Scale (HAM-A). In addition, clinical effects were assessed on the basis of the size of the surface area, rate of healing, and concentration of pro-inflammatory factors (IL-1, IL-6, TNF-α) and growth factors (VEGF, bFGF, TGF-β1). Results Compared with the control group, the VAS score and HAM-A score in the experimental groups were significantly decreased after intervention (P < 0.05). After intervention, the levels of IL-1β, IL-6, and TNF-α in AWEG, IPTEG, and CPTEG were significantly lower than those in AWCG. In addition, the levels of VEGF, bFGF, and TGF-β1 in IPTEG and CPTEG were significantly higher than those in CWCG (P < 0.05). Conclusion These results indicated that comfort therapy under the eCASH concept has a significant effect on ameliorating the pain and anxiety of patients, reducing the inflammatory reaction during the period of wound healing in the treatment of acute and chronic wounds. Clinical Trial Registry The trial has been registered in the Chinese Clinical Trial Registry (ChiCTR2200057981).https://doi.org/10.1007/s13555-022-00852-5Comfort therapyContinuous negative pressure therapy (CNPWT)eCASHHamilton Anxiety Scale (HAM-A)Intermittent negative pressure wound therapy (INPWT)Visual Analogue Score (VAS) |
| spellingShingle | Shuting Shi Jiayu Wei Guozhong Lyu Xiaohui Zhong Minlie Yang Lihong Zhu Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound Treatment Dermatology and Therapy Comfort therapy Continuous negative pressure therapy (CNPWT) eCASH Hamilton Anxiety Scale (HAM-A) Intermittent negative pressure wound therapy (INPWT) Visual Analogue Score (VAS) |
| title | Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound Treatment |
| title_full | Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound Treatment |
| title_fullStr | Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound Treatment |
| title_full_unstemmed | Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound Treatment |
| title_short | Application of Comfort Therapy under eCASH Concept in Acute and Chronic Wound Treatment |
| title_sort | application of comfort therapy under ecash concept in acute and chronic wound treatment |
| topic | Comfort therapy Continuous negative pressure therapy (CNPWT) eCASH Hamilton Anxiety Scale (HAM-A) Intermittent negative pressure wound therapy (INPWT) Visual Analogue Score (VAS) |
| url | https://doi.org/10.1007/s13555-022-00852-5 |
| work_keys_str_mv | AT shutingshi applicationofcomforttherapyunderecashconceptinacuteandchronicwoundtreatment AT jiayuwei applicationofcomforttherapyunderecashconceptinacuteandchronicwoundtreatment AT guozhonglyu applicationofcomforttherapyunderecashconceptinacuteandchronicwoundtreatment AT xiaohuizhong applicationofcomforttherapyunderecashconceptinacuteandchronicwoundtreatment AT minlieyang applicationofcomforttherapyunderecashconceptinacuteandchronicwoundtreatment AT lihongzhu applicationofcomforttherapyunderecashconceptinacuteandchronicwoundtreatment |