Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia
Abstract This study intended to explore the neuropsychological ramifications in childhood acute lymphoblastic leukemia (ALL) survivors in Malaysia and to examine treatment-related sequelae. A case-control study was conducted over a 2-year period. Seventy-one survivors of childhood ALL who had comple...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-58128-1 |
| _version_ | 1797209428451131392 |
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| author | Hamidah Alias Norashikin Mohd Ranai Sie Chong Doris Lau Leo M. J. de Sonneville |
| author_facet | Hamidah Alias Norashikin Mohd Ranai Sie Chong Doris Lau Leo M. J. de Sonneville |
| author_sort | Hamidah Alias |
| collection | DOAJ |
| description | Abstract This study intended to explore the neuropsychological ramifications in childhood acute lymphoblastic leukemia (ALL) survivors in Malaysia and to examine treatment-related sequelae. A case-control study was conducted over a 2-year period. Seventy-one survivors of childhood ALL who had completed treatment for a minimum of 1 year and were in remission, and 71 healthy volunteers were enlisted. To assess alertness (processing speed) and essential executive functioning skills such as working memory capacity, inhibition, cognitive flexibility, and sustained attention, seven measures from the Amsterdam Neuropsychological Tasks (ANT) program were chosen. Main outcome measures were speed, stability and accuracy of responses. Mean age at diagnosis was 4.50 years (SD ± 2.40) while mean age at study entry was 12.18 years (SD ± 3.14). Survivors of childhood ALL underperformed on 6 out of 7 ANT tasks, indicating poorer sustained attention, working memory capacity, executive visuomotor control, and cognitive flexibility. Duration of treatment, age at diagnosis, gender, and cumulative doses of chemotherapy were not found to correlate with any of the neuropsychological outcome measures. Childhood ALL survivors in our center demonstrated significantly poorer neuropsychological status compared to healthy controls. |
| first_indexed | 2024-04-24T09:54:33Z |
| format | Article |
| id | doaj.art-a00e2f3a6c444edea32520cb2de650bb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T09:54:33Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a00e2f3a6c444edea32520cb2de650bb2024-04-14T11:14:08ZengNature PortfolioScientific Reports2045-23222024-04-0114111210.1038/s41598-024-58128-1Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in MalaysiaHamidah Alias0Norashikin Mohd Ranai1Sie Chong Doris Lau2Leo M. J. de Sonneville3Department of Pediatrics, Faculty of Medicine, The National University of MalaysiaDepartment of Pediatrics, Faculty of Medicine, Universiti Teknologi Mara (UiTM)Department of Pediatrics, Faculty of Medicine, The National University of MalaysiaClinical Neurodevelopmental Sciences, Faculty of Social Sciences, Leiden UniversityAbstract This study intended to explore the neuropsychological ramifications in childhood acute lymphoblastic leukemia (ALL) survivors in Malaysia and to examine treatment-related sequelae. A case-control study was conducted over a 2-year period. Seventy-one survivors of childhood ALL who had completed treatment for a minimum of 1 year and were in remission, and 71 healthy volunteers were enlisted. To assess alertness (processing speed) and essential executive functioning skills such as working memory capacity, inhibition, cognitive flexibility, and sustained attention, seven measures from the Amsterdam Neuropsychological Tasks (ANT) program were chosen. Main outcome measures were speed, stability and accuracy of responses. Mean age at diagnosis was 4.50 years (SD ± 2.40) while mean age at study entry was 12.18 years (SD ± 3.14). Survivors of childhood ALL underperformed on 6 out of 7 ANT tasks, indicating poorer sustained attention, working memory capacity, executive visuomotor control, and cognitive flexibility. Duration of treatment, age at diagnosis, gender, and cumulative doses of chemotherapy were not found to correlate with any of the neuropsychological outcome measures. Childhood ALL survivors in our center demonstrated significantly poorer neuropsychological status compared to healthy controls.https://doi.org/10.1038/s41598-024-58128-1 |
| spellingShingle | Hamidah Alias Norashikin Mohd Ranai Sie Chong Doris Lau Leo M. J. de Sonneville Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia Scientific Reports |
| title | Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia |
| title_full | Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia |
| title_fullStr | Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia |
| title_full_unstemmed | Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia |
| title_short | Neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in Malaysia |
| title_sort | neuropsychological task outcomes among survivors of childhood acute lymphoblastic leukemia in malaysia |
| url | https://doi.org/10.1038/s41598-024-58128-1 |
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