Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma
Almost 75% of renal cancers are renal clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations are closely related to the development of KIRC. Cancer immunotherapy is an effective treatment for cancers. The aim of this study was to identify immune-related differen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.750997/full |
| _version_ | 1818742180540317696 |
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| author | Zhi-Yong Yao Zhi-Yong Yao Chaoqung Xing Yuan-Wu Liu Xiao-Liang Xing Xiao-Liang Xing |
| author_facet | Zhi-Yong Yao Zhi-Yong Yao Chaoqung Xing Yuan-Wu Liu Xiao-Liang Xing Xiao-Liang Xing |
| author_sort | Zhi-Yong Yao |
| collection | DOAJ |
| description | Almost 75% of renal cancers are renal clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations are closely related to the development of KIRC. Cancer immunotherapy is an effective treatment for cancers. The aim of this study was to identify immune-related differentially expressed genes (IR-DEGs) associated with aberrant methylations and construct a risk assessment model using these IR-DEGs to predict the prognosis of KIRC. Two IR-DEGs (SLC11A1 and TNFSF14) were identified by differential expression, correlation analysis, and Cox regression analysis, and risk assessment models were established. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.6907. In addition, we found that risk scores were significantly associated with 31 immune cells and factors. Our present study not only shows that two IR-DEGs can be used as prognosis signatures for KIRC, but also provides a strategy for the screening of suitable prognosis signatures associated with aberrant methylation in other cancers. |
| first_indexed | 2024-12-18T02:08:25Z |
| format | Article |
| id | doaj.art-a00eef66941149b9b143a98a63c7ce25 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-18T02:08:25Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a00eef66941149b9b143a98a63c7ce252022-12-21T21:24:33ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-12-011210.3389/fgene.2021.750997750997Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell CarcinomaZhi-Yong Yao0Zhi-Yong Yao1Chaoqung Xing2Yuan-Wu Liu3Xiao-Liang Xing4Xiao-Liang Xing5School of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, ChinaThe First Affiliated Hospital of Hunan University of Medicine, Huaihua, ChinaSchool of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, ChinaSchool of Public Health and Laboratory Medicine, Hunan University of Medicine, Huaihua, ChinaThe First Affiliated Hospital of Hunan University of Medicine, Huaihua, ChinaAlmost 75% of renal cancers are renal clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations are closely related to the development of KIRC. Cancer immunotherapy is an effective treatment for cancers. The aim of this study was to identify immune-related differentially expressed genes (IR-DEGs) associated with aberrant methylations and construct a risk assessment model using these IR-DEGs to predict the prognosis of KIRC. Two IR-DEGs (SLC11A1 and TNFSF14) were identified by differential expression, correlation analysis, and Cox regression analysis, and risk assessment models were established. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.6907. In addition, we found that risk scores were significantly associated with 31 immune cells and factors. Our present study not only shows that two IR-DEGs can be used as prognosis signatures for KIRC, but also provides a strategy for the screening of suitable prognosis signatures associated with aberrant methylation in other cancers.https://www.frontiersin.org/articles/10.3389/fgene.2021.750997/fullKIRCDEGsDMPSimmune-relatedprognosis |
| spellingShingle | Zhi-Yong Yao Zhi-Yong Yao Chaoqung Xing Yuan-Wu Liu Xiao-Liang Xing Xiao-Liang Xing Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma Frontiers in Genetics KIRC DEGs DMPS immune-related prognosis |
| title | Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma |
| title_full | Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma |
| title_fullStr | Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma |
| title_full_unstemmed | Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma |
| title_short | Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma |
| title_sort | identification of two immune related genes correlated with aberrant methylations as prognosis signatures for renal clear cell carcinoma |
| topic | KIRC DEGs DMPS immune-related prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.750997/full |
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