Adverse childhood experience and depression: the role of gut microbiota
Depression is the most common psychiatric disorder that burdens modern society heavily. Numerous studies have shown that adverse childhood experiences can increase susceptibility to depression, and depression with adverse childhood experiences has specific clinical-biological features. However, the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1309022/full |
| _version_ | 1797229397538766848 |
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| author | Yu Bai Chang Shu Ying Hou Gao-Hua Wang |
| author_facet | Yu Bai Chang Shu Ying Hou Gao-Hua Wang |
| author_sort | Yu Bai |
| collection | DOAJ |
| description | Depression is the most common psychiatric disorder that burdens modern society heavily. Numerous studies have shown that adverse childhood experiences can increase susceptibility to depression, and depression with adverse childhood experiences has specific clinical-biological features. However, the specific neurobiological mechanisms are not yet precise. Recent studies suggest that the gut microbiota can influence brain function and behavior associated with depression through the “microbe-gut-brain axis” and that the composition and function of the gut microbiota are influenced by early stress. These studies offer a possibility that gut microbiota mediates the relationship between adverse childhood experiences and depression. However, few studies directly link adverse childhood experiences, gut microbiota, and depression. This article reviews recent studies on the relationship among adverse childhood experiences, gut microbiota, and depression, intending to provide insights for new research. |
| first_indexed | 2024-04-24T15:11:57Z |
| format | Article |
| id | doaj.art-a011c9344fea45b0abf7aeeba9caf02b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-24T15:11:57Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a011c9344fea45b0abf7aeeba9caf02b2024-04-02T10:39:03ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-04-011510.3389/fpsyt.2024.13090221309022Adverse childhood experience and depression: the role of gut microbiotaYu Bai0Chang Shu1Ying Hou2Gao-Hua Wang3Department of Psychiatry, Renmin Hospital of Wuhan University, Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaPeking University China-Japan Friendship School of Clinical Medicine, Department of Neurology, Beijing, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepression is the most common psychiatric disorder that burdens modern society heavily. Numerous studies have shown that adverse childhood experiences can increase susceptibility to depression, and depression with adverse childhood experiences has specific clinical-biological features. However, the specific neurobiological mechanisms are not yet precise. Recent studies suggest that the gut microbiota can influence brain function and behavior associated with depression through the “microbe-gut-brain axis” and that the composition and function of the gut microbiota are influenced by early stress. These studies offer a possibility that gut microbiota mediates the relationship between adverse childhood experiences and depression. However, few studies directly link adverse childhood experiences, gut microbiota, and depression. This article reviews recent studies on the relationship among adverse childhood experiences, gut microbiota, and depression, intending to provide insights for new research.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1309022/fulladverse childhood experiencesgut-brain axisdepressive disordergut microbiotastress |
| spellingShingle | Yu Bai Chang Shu Ying Hou Gao-Hua Wang Adverse childhood experience and depression: the role of gut microbiota Frontiers in Psychiatry adverse childhood experiences gut-brain axis depressive disorder gut microbiota stress |
| title | Adverse childhood experience and depression: the role of gut microbiota |
| title_full | Adverse childhood experience and depression: the role of gut microbiota |
| title_fullStr | Adverse childhood experience and depression: the role of gut microbiota |
| title_full_unstemmed | Adverse childhood experience and depression: the role of gut microbiota |
| title_short | Adverse childhood experience and depression: the role of gut microbiota |
| title_sort | adverse childhood experience and depression the role of gut microbiota |
| topic | adverse childhood experiences gut-brain axis depressive disorder gut microbiota stress |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1309022/full |
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