Autocrine and paracrine regulatory functions of platelet serotonin
Platelets serotonin (5-hydroxytrytamine, 5-HT) uptake and storage in dense granules is tightly regulated by the serotonergic transport system in the blood. Several 5-HT transporters (5-HTTs) have been identified in the vasculature and blood cells, beyond them 5-HTT is the major 5-HT transporter in p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-08-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1478072 |
| _version_ | 1797684283332100096 |
|---|---|
| author | Elmina Mammadova-Bach Maximilian Mauler Attila Braun Daniel Duerschmied |
| author_facet | Elmina Mammadova-Bach Maximilian Mauler Attila Braun Daniel Duerschmied |
| author_sort | Elmina Mammadova-Bach |
| collection | DOAJ |
| description | Platelets serotonin (5-hydroxytrytamine, 5-HT) uptake and storage in dense granules is tightly regulated by the serotonergic transport system in the blood. Several 5-HT transporters (5-HTTs) have been identified in the vasculature and blood cells, beyond them 5-HTT is the major 5-HT transporter in platelets. Abnormal 5-HT concentrations in the blood plasma or increased platelet 5-HT uptake or abnormal release contribute to the development of various diseases in the vasculature. Consequently, several clinical trials suggested the positive therapeutic effects of 5-HTT blockade in the circulation. Inhibition of 5-HT strongly attenuates autocrine and paracrine functions of platelets, influencing platelet aggregation, vascular contraction, permeability, tissue repair, wound healing, immunity and cancer. Here, we highlight the current state of basic biological research regarding the hemostatic and non-hemostatic functions of platelet-derived 5-HT in normal and disease conditions. We also describe the physiological consequences of targeting platelet 5-HT functions in thrombosis, stroke, inflammation and cancer to overcome common health problems. |
| first_indexed | 2024-03-12T00:27:12Z |
| format | Article |
| id | doaj.art-a011e7f41046496784f5db6571d3c3f0 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:12Z |
| publishDate | 2018-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-a011e7f41046496784f5db6571d3c3f02023-09-15T10:31:59ZengTaylor & Francis GroupPlatelets0953-71041369-16352018-08-0129654154810.1080/09537104.2018.14780721478072Autocrine and paracrine regulatory functions of platelet serotoninElmina Mammadova-Bach0Maximilian Mauler1Attila Braun2Daniel Duerschmied3University Hospital and Rudolf Virchow CenterUniversity of FreiburgUniversity Hospital and Rudolf Virchow CenterUniversity of FreiburgPlatelets serotonin (5-hydroxytrytamine, 5-HT) uptake and storage in dense granules is tightly regulated by the serotonergic transport system in the blood. Several 5-HT transporters (5-HTTs) have been identified in the vasculature and blood cells, beyond them 5-HTT is the major 5-HT transporter in platelets. Abnormal 5-HT concentrations in the blood plasma or increased platelet 5-HT uptake or abnormal release contribute to the development of various diseases in the vasculature. Consequently, several clinical trials suggested the positive therapeutic effects of 5-HTT blockade in the circulation. Inhibition of 5-HT strongly attenuates autocrine and paracrine functions of platelets, influencing platelet aggregation, vascular contraction, permeability, tissue repair, wound healing, immunity and cancer. Here, we highlight the current state of basic biological research regarding the hemostatic and non-hemostatic functions of platelet-derived 5-HT in normal and disease conditions. We also describe the physiological consequences of targeting platelet 5-HT functions in thrombosis, stroke, inflammation and cancer to overcome common health problems.http://dx.doi.org/10.1080/09537104.2018.1478072immune functionsplatelet serotoninsignalingtryptophan hydroxylase |
| spellingShingle | Elmina Mammadova-Bach Maximilian Mauler Attila Braun Daniel Duerschmied Autocrine and paracrine regulatory functions of platelet serotonin Platelets immune functions platelet serotonin signaling tryptophan hydroxylase |
| title | Autocrine and paracrine regulatory functions of platelet serotonin |
| title_full | Autocrine and paracrine regulatory functions of platelet serotonin |
| title_fullStr | Autocrine and paracrine regulatory functions of platelet serotonin |
| title_full_unstemmed | Autocrine and paracrine regulatory functions of platelet serotonin |
| title_short | Autocrine and paracrine regulatory functions of platelet serotonin |
| title_sort | autocrine and paracrine regulatory functions of platelet serotonin |
| topic | immune functions platelet serotonin signaling tryptophan hydroxylase |
| url | http://dx.doi.org/10.1080/09537104.2018.1478072 |
| work_keys_str_mv | AT elminamammadovabach autocrineandparacrineregulatoryfunctionsofplateletserotonin AT maximilianmauler autocrineandparacrineregulatoryfunctionsofplateletserotonin AT attilabraun autocrineandparacrineregulatoryfunctionsofplateletserotonin AT danielduerschmied autocrineandparacrineregulatoryfunctionsofplateletserotonin |