Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis
We reported a rare case of acute liver injury in a patient with chronic hepatitis C virus infection without cirrhosis 4 weeks after initiation of glecaprevir/pibrentasvir. After prompt cessation of antiviral therapy, liver enzymes rapidly improved toward baseline. This case reflects the need to rema...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2022-07-01
|
| Series: | Avicenna Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750716 |
| _version_ | 1828111993317359616 |
|---|---|
| author | Ayushi Jain Khalid Mumtaz |
| author_facet | Ayushi Jain Khalid Mumtaz |
| author_sort | Ayushi Jain |
| collection | DOAJ |
| description | We reported a rare case of acute liver injury in a patient with chronic hepatitis C virus infection without cirrhosis 4 weeks after initiation of glecaprevir/pibrentasvir. After prompt cessation of antiviral therapy, liver enzymes rapidly improved toward baseline. This case reflects the need to remain vigilant for the development of acute liver injury after initiation of glecaprevir/pibrentasvir even without a diagnosis of cirrhosis. |
| first_indexed | 2024-04-11T11:43:37Z |
| format | Article |
| id | doaj.art-a0126ccace2d403eba03ecb9d2b34f9a |
| institution | Directory Open Access Journal |
| issn | 2231-0770 2249-4464 |
| language | English |
| last_indexed | 2024-04-11T11:43:37Z |
| publishDate | 2022-07-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Avicenna Journal of Medicine |
| spelling | doaj.art-a0126ccace2d403eba03ecb9d2b34f9a2022-12-22T04:25:43ZengThieme Medical and Scientific Publishers Pvt. Ltd.Avicenna Journal of Medicine2231-07702249-44642022-07-01120315415610.1055/s-0042-1750716Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without CirrhosisAyushi Jain0Khalid Mumtaz1Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, United StatesDivision of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, United StatesWe reported a rare case of acute liver injury in a patient with chronic hepatitis C virus infection without cirrhosis 4 weeks after initiation of glecaprevir/pibrentasvir. After prompt cessation of antiviral therapy, liver enzymes rapidly improved toward baseline. This case reflects the need to remain vigilant for the development of acute liver injury after initiation of glecaprevir/pibrentasvir even without a diagnosis of cirrhosis.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750716acute liver injurydrug induced liver injuryhepatitis cglecaprevir/pibrentasvir |
| spellingShingle | Ayushi Jain Khalid Mumtaz Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis Avicenna Journal of Medicine acute liver injury drug induced liver injury hepatitis c glecaprevir/pibrentasvir |
| title | Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis |
| title_full | Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis |
| title_fullStr | Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis |
| title_full_unstemmed | Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis |
| title_short | Acute Liver Injury due to Glecaprevir/Pibrentasvir in a Patient with Chronic Hepatitis C Virus Infection without Cirrhosis |
| title_sort | acute liver injury due to glecaprevir pibrentasvir in a patient with chronic hepatitis c virus infection without cirrhosis |
| topic | acute liver injury drug induced liver injury hepatitis c glecaprevir/pibrentasvir |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750716 |
| work_keys_str_mv | AT ayushijain acuteliverinjuryduetoglecaprevirpibrentasvirinapatientwithchronichepatitiscvirusinfectionwithoutcirrhosis AT khalidmumtaz acuteliverinjuryduetoglecaprevirpibrentasvirinapatientwithchronichepatitiscvirusinfectionwithoutcirrhosis |