Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Purpose: Glioblastoma(GBM) is a lethal disease characterized by inevitable recurrence. Here we investigate the molecular pathways mediating resistance, with the goal of identifying novel therapeutic opportunities. Experimental design: We developed a longitudinal in vivo recurrence model utilizing pa...

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Bibliographic Details
Main Authors: Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel GW Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C de Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Subclonal evolution
Treatment resistance
Glioblastoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000975

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