Gaining insight into the neural basis of resting-state fMRI signal
The blood oxygenation level-dependent (BOLD)-based resting-state functional magnetic resonance imaging (rsfMRI) has been widely used as a non-invasive tool to map brain-wide connectivity architecture. However, the neural basis underpinning the resting-state BOLD signal remains elusive. In this study...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922000891 |
| _version_ | 1818330887539916800 |
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| author | Zilu Ma Qingqing Zhang Wenyu Tu Nanyin Zhang |
| author_facet | Zilu Ma Qingqing Zhang Wenyu Tu Nanyin Zhang |
| author_sort | Zilu Ma |
| collection | DOAJ |
| description | The blood oxygenation level-dependent (BOLD)-based resting-state functional magnetic resonance imaging (rsfMRI) has been widely used as a non-invasive tool to map brain-wide connectivity architecture. However, the neural basis underpinning the resting-state BOLD signal remains elusive. In this study, we combined simultaneous calcium-based fiber photometry with rsfMRI in awake animals to examine the relationship of the BOLD signal and spiking activity at the resting state. We observed robust couplings between calcium and BOLD signals in the dorsal hippocampus as well as other distributed areas in the default mode network (DMN), suggesting that the calcium measurement can reliably predict the rsfMRI signal. In addition, using the calcium signal recorded as the ground truth, we assessed the impacts of different rsfMRI data preprocessing pipelines on functional connectivity mapping. Overall, our results provide important evidence suggesting that spiking activity measured by the calcium signal plays a key role in the neural mechanism of resting-state BOLD signal. |
| first_indexed | 2024-12-13T13:11:06Z |
| format | Article |
| id | doaj.art-a01414a8a9fc48f99e6f3edc02dfe00e |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-13T13:11:06Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-a01414a8a9fc48f99e6f3edc02dfe00e2022-12-21T23:44:42ZengElsevierNeuroImage1095-95722022-04-01250118960Gaining insight into the neural basis of resting-state fMRI signalZilu Ma0Qingqing Zhang1Wenyu Tu2Nanyin Zhang3Department of Biomedical Engineering, The Pennsylvania State University, University Park, USADepartment of Biomedical Engineering, The Pennsylvania State University, University Park, USAThe Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, USADepartment of Biomedical Engineering, The Pennsylvania State University, University Park, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, USA; Corresponding author.The blood oxygenation level-dependent (BOLD)-based resting-state functional magnetic resonance imaging (rsfMRI) has been widely used as a non-invasive tool to map brain-wide connectivity architecture. However, the neural basis underpinning the resting-state BOLD signal remains elusive. In this study, we combined simultaneous calcium-based fiber photometry with rsfMRI in awake animals to examine the relationship of the BOLD signal and spiking activity at the resting state. We observed robust couplings between calcium and BOLD signals in the dorsal hippocampus as well as other distributed areas in the default mode network (DMN), suggesting that the calcium measurement can reliably predict the rsfMRI signal. In addition, using the calcium signal recorded as the ground truth, we assessed the impacts of different rsfMRI data preprocessing pipelines on functional connectivity mapping. Overall, our results provide important evidence suggesting that spiking activity measured by the calcium signal plays a key role in the neural mechanism of resting-state BOLD signal.http://www.sciencedirect.com/science/article/pii/S1053811922000891Resting-state fMRIGCaMPPreprocessingAwakeRat |
| spellingShingle | Zilu Ma Qingqing Zhang Wenyu Tu Nanyin Zhang Gaining insight into the neural basis of resting-state fMRI signal NeuroImage Resting-state fMRI GCaMP Preprocessing Awake Rat |
| title | Gaining insight into the neural basis of resting-state fMRI signal |
| title_full | Gaining insight into the neural basis of resting-state fMRI signal |
| title_fullStr | Gaining insight into the neural basis of resting-state fMRI signal |
| title_full_unstemmed | Gaining insight into the neural basis of resting-state fMRI signal |
| title_short | Gaining insight into the neural basis of resting-state fMRI signal |
| title_sort | gaining insight into the neural basis of resting state fmri signal |
| topic | Resting-state fMRI GCaMP Preprocessing Awake Rat |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922000891 |
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