Targeting microRNA for improved skin health
Abstract Background In human skin, miRNAs have important regulatory roles and are involved in the development, morphogenesis, and maintenance by influencing cell proliferation, differentiation, immune regulation, and wound healing. MiRNAs have been investigated for many years in various skin disorde...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.374 |
| _version_ | 1818774435911434240 |
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| author | Xi Li Sakthi Ponandai‐Srinivasan Kutty Selva Nandakumar Susanne Fabre Ning Xu Landén Alain Mavon Ia Khmaladze |
| author_facet | Xi Li Sakthi Ponandai‐Srinivasan Kutty Selva Nandakumar Susanne Fabre Ning Xu Landén Alain Mavon Ia Khmaladze |
| author_sort | Xi Li |
| collection | DOAJ |
| description | Abstract Background In human skin, miRNAs have important regulatory roles and are involved in the development, morphogenesis, and maintenance by influencing cell proliferation, differentiation, immune regulation, and wound healing. MiRNAs have been investigated for many years in various skin disorders such as atopic dermatitis, psoriasis, as well as malignant tumors. Only during recent times, cosmeceutical use of molecules/natural active ingredients to regulate miRNA expression for significant advances in skin health/care product development was recognized. Aim To review miRNAs with the potential to maintain and boost skin health and avoid premature aging by improving barrier function, preventing photoaging, hyperpigmentation, and chronological aging/senescence. Methods Most of the cited articles were found through literature search on PubMed. The main search criteria was a keyword “skin” in combination with the following words: miRNA, photoaging, UV, barrier, aging, exposome, acne, wound healing, pigmentation, pollution, and senescence. Most of the articles reviewed for relevancy were published during the past 10 years. Results All results are summarized in Figure 1, and they are based on cited references. Conclusions Thus, regulating miRNAs expression is a promising approach for novel therapy not only for targeting skin diseases but also for cosmeceutical interventions aiming to boost skin health. |
| first_indexed | 2024-12-18T10:41:06Z |
| format | Article |
| id | doaj.art-a0160732130c4fba9dacf00b027febe1 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-12-18T10:41:06Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-a0160732130c4fba9dacf00b027febe12022-12-21T21:10:40ZengWileyHealth Science Reports2398-88352021-12-0144n/an/a10.1002/hsr2.374Targeting microRNA for improved skin healthXi Li0Sakthi Ponandai‐Srinivasan1Kutty Selva Nandakumar2Susanne Fabre3Ning Xu Landén4Alain Mavon5Ia Khmaladze6Oriflame Cosmetics AB; Skin Research Institute Stockholm SwedenDivision of Obstetrics and Gynecology, Department of Women's and Children's Health Karolinska Institute, and Karolinska University Hospital Stockholm SwedenSouthern Medical University, School of Pharmaceutical Sciences Guangzhou ChinaOriflame Cosmetics AB; Skin Research Institute Stockholm SwedenDepartment of Medicine, Solna, Dermatology and Venereology, Centre of Molecular Medicine Karolinska Institutet Stockholm SwedenOriflame Cosmetics AB; Skin Research Institute Stockholm SwedenOriflame Cosmetics AB; Skin Research Institute Stockholm SwedenAbstract Background In human skin, miRNAs have important regulatory roles and are involved in the development, morphogenesis, and maintenance by influencing cell proliferation, differentiation, immune regulation, and wound healing. MiRNAs have been investigated for many years in various skin disorders such as atopic dermatitis, psoriasis, as well as malignant tumors. Only during recent times, cosmeceutical use of molecules/natural active ingredients to regulate miRNA expression for significant advances in skin health/care product development was recognized. Aim To review miRNAs with the potential to maintain and boost skin health and avoid premature aging by improving barrier function, preventing photoaging, hyperpigmentation, and chronological aging/senescence. Methods Most of the cited articles were found through literature search on PubMed. The main search criteria was a keyword “skin” in combination with the following words: miRNA, photoaging, UV, barrier, aging, exposome, acne, wound healing, pigmentation, pollution, and senescence. Most of the articles reviewed for relevancy were published during the past 10 years. Results All results are summarized in Figure 1, and they are based on cited references. Conclusions Thus, regulating miRNAs expression is a promising approach for novel therapy not only for targeting skin diseases but also for cosmeceutical interventions aiming to boost skin health.https://doi.org/10.1002/hsr2.374cosmeticsmicroRNASkin health |
| spellingShingle | Xi Li Sakthi Ponandai‐Srinivasan Kutty Selva Nandakumar Susanne Fabre Ning Xu Landén Alain Mavon Ia Khmaladze Targeting microRNA for improved skin health Health Science Reports cosmetics microRNA Skin health |
| title | Targeting microRNA for improved skin health |
| title_full | Targeting microRNA for improved skin health |
| title_fullStr | Targeting microRNA for improved skin health |
| title_full_unstemmed | Targeting microRNA for improved skin health |
| title_short | Targeting microRNA for improved skin health |
| title_sort | targeting microrna for improved skin health |
| topic | cosmetics microRNA Skin health |
| url | https://doi.org/10.1002/hsr2.374 |
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