Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002
BackgroundDietary habits and dietary intake affect telomere length, a reliable marker of biological aging and a predictor of chronic disease. Riboflavin (RF) is known as a water-soluble antioxidant vitamin, but its role in telomere length maintenance has yet to be elucidated.ObjectiveThe purpose of...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.744397/full |
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| author | Weihua Chen Weihua Chen Shanshan Shi Shanshan Shi Yizhou Jiang Liling Chen Ying Liao Kaihong Chen Kun Huang |
| author_facet | Weihua Chen Weihua Chen Shanshan Shi Shanshan Shi Yizhou Jiang Liling Chen Ying Liao Kaihong Chen Kun Huang |
| author_sort | Weihua Chen |
| collection | DOAJ |
| description | BackgroundDietary habits and dietary intake affect telomere length, a reliable marker of biological aging and a predictor of chronic disease. Riboflavin (RF) is known as a water-soluble antioxidant vitamin, but its role in telomere length maintenance has yet to be elucidated.ObjectiveThe purpose of this study was to examine the relationship between dietary RF intake and telomere length in a nationally representative sample of adults.MethodsUsing the NHANES (1999–2002), telomere data of 4,298 participants aged ≥45 years were analyzed in a cross-sectional manner. Leukocyte telomere length was measured using the quantitative real-time polymerase chain reaction (qPCR). Dietary RF intake was assessed by a trained interviewer using 24-h dietary recall method. Generalized linear regressions were performed to evaluate the association between dietary RF intake and telomere length. Subgroup analyses were performed to further explore this relationship in sex and body mass index (BMI) subgroups.ResultsAmong the 3,788 participants included, the average telomere length was longer in females (P = 0.014), while they had a lower average RF intake compared to males (P < 0.001). There was a weak positive correlation between RF intake and telomere length both when unadjusted (β = 0.011; P = 0.037) and adjusted for age, sex, and ethnicity (β = 0.013; P = 0.033). Subgroup analyses showed a positive association between RF intake and the telomere length in female after adjusting for confounding factors (β = 0.029; P = 0.046). In the female subgroup, there were significant positive relationships between telomere length and RF intake in the obese group (β = 0.086, P = 0.022).ConclusionIncreased dietary RF intake was significantly associated with longer telomere length in middle-aged and older American females, especially in low RF intake obese female. |
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| language | English |
| last_indexed | 2024-04-12T22:41:44Z |
| publishDate | 2022-03-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-a01647841af84104901babf885500fa02022-12-22T03:13:42ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-03-01910.3389/fnut.2022.744397744397Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002Weihua Chen0Weihua Chen1Shanshan Shi2Shanshan Shi3Yizhou Jiang4Liling Chen5Ying Liao6Kaihong Chen7Kun Huang8Longyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaThe Third Clinical Medical College, Fujian Medical University, Fuzhou, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaThe Third Clinical Medical College, Fujian Medical University, Fuzhou, ChinaState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaLongyan First Affiliated Hospital of Fujian Medical University, Longyan, ChinaCenter for Statistical Science, Department of Industrial Engineering, Tsinghua University, Beijing, ChinaBackgroundDietary habits and dietary intake affect telomere length, a reliable marker of biological aging and a predictor of chronic disease. Riboflavin (RF) is known as a water-soluble antioxidant vitamin, but its role in telomere length maintenance has yet to be elucidated.ObjectiveThe purpose of this study was to examine the relationship between dietary RF intake and telomere length in a nationally representative sample of adults.MethodsUsing the NHANES (1999–2002), telomere data of 4,298 participants aged ≥45 years were analyzed in a cross-sectional manner. Leukocyte telomere length was measured using the quantitative real-time polymerase chain reaction (qPCR). Dietary RF intake was assessed by a trained interviewer using 24-h dietary recall method. Generalized linear regressions were performed to evaluate the association between dietary RF intake and telomere length. Subgroup analyses were performed to further explore this relationship in sex and body mass index (BMI) subgroups.ResultsAmong the 3,788 participants included, the average telomere length was longer in females (P = 0.014), while they had a lower average RF intake compared to males (P < 0.001). There was a weak positive correlation between RF intake and telomere length both when unadjusted (β = 0.011; P = 0.037) and adjusted for age, sex, and ethnicity (β = 0.013; P = 0.033). Subgroup analyses showed a positive association between RF intake and the telomere length in female after adjusting for confounding factors (β = 0.029; P = 0.046). In the female subgroup, there were significant positive relationships between telomere length and RF intake in the obese group (β = 0.086, P = 0.022).ConclusionIncreased dietary RF intake was significantly associated with longer telomere length in middle-aged and older American females, especially in low RF intake obese female.https://www.frontiersin.org/articles/10.3389/fnut.2022.744397/fullriboflavindietary intaketelomere lengthNHANESobesefemale |
| spellingShingle | Weihua Chen Weihua Chen Shanshan Shi Shanshan Shi Yizhou Jiang Liling Chen Ying Liao Kaihong Chen Kun Huang Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002 Frontiers in Nutrition riboflavin dietary intake telomere length NHANES obese female |
| title | Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002 |
| title_full | Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002 |
| title_fullStr | Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002 |
| title_full_unstemmed | Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002 |
| title_short | Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002 |
| title_sort | association between riboflavin intake and telomere length a cross sectional study from national health and nutrition examination survey 1999 2002 |
| topic | riboflavin dietary intake telomere length NHANES obese female |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.744397/full |
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