The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis
Abstract Coronavirus disease (COVID‐19) affects both the respiratory system and the body as a whole. Natural molecules, such as flavonoid quercetin, as potential treatment methods to help patients combat COVID‐19. The aim of this systematic review and meta‐analysis is to give a comprehensive overvie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Food Science & Nutrition |
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| Online Access: | https://doi.org/10.1002/fsn3.3715 |
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| author | Somayeh Ziaei Malek Alimohammadi‐Kamalabadi Motahareh Hasani Mahsa Malekahmadi Emma Persad Javad Heshmati |
| author_facet | Somayeh Ziaei Malek Alimohammadi‐Kamalabadi Motahareh Hasani Mahsa Malekahmadi Emma Persad Javad Heshmati |
| author_sort | Somayeh Ziaei |
| collection | DOAJ |
| description | Abstract Coronavirus disease (COVID‐19) affects both the respiratory system and the body as a whole. Natural molecules, such as flavonoid quercetin, as potential treatment methods to help patients combat COVID‐19. The aim of this systematic review and meta‐analysis is to give a comprehensive overview of the impact of quercetin supplementation on inflammatory factors, hospital admission, and mortality of patients with COVID‐19. The search has been conducted on PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library using relevant keywords until August 25, 2023. We included randomized controlled trials (RCTs) comparing COVID‐19 patients who received quercetin supplementation versus controls. We included five studies summarizing the evidence in 544 patients. Meta‐analysis showed that quercetin administration significantly reduced LDH activity (standard mean difference (SMD): −0.42, 95% CI: −0.82, −0.02, I2 = 48.86%), decreased the risk of hospital admission by 70% (RR: 0.30, 95% CI: 0.14, 0.62, I2 = 00.00%), ICU admission by 73% (RR: 0.27, 95% CI: 0.09, 0.78, I2 = 20.66%), and mortality by 82% (RR: 0.18, 95% CI: 0.03, 0.98, I2 = 00.00%). No significant changes in CRP, D‐dimmer, and ferritin were found between groups. Quercetin was found to significantly reduce LDH levels and decrease the risk of hospital and ICU admission and mortality in patients with COVID‐19 infection. |
| first_indexed | 2024-03-08T22:53:46Z |
| format | Article |
| id | doaj.art-a01818ab2a5b4ff4bd27730335d859ba |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-03-08T22:53:46Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-a01818ab2a5b4ff4bd27730335d859ba2023-12-16T07:01:19ZengWileyFood Science & Nutrition2048-71772023-12-0111127504751410.1002/fsn3.3715The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysisSomayeh Ziaei0Malek Alimohammadi‐Kamalabadi1Motahareh Hasani2Mahsa Malekahmadi3Emma Persad4Javad Heshmati5ICU Department, Emam Reza Hospital Kermanshah University of Medical Sciences Kermanshah IranDepartment of Cellular‐Molecular Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran IranDepartment of Nutritional Sciences, School of Health Golestan University of Medical Sciences Gorgan IranDepartment of Cellular‐Molecular Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran IranDepartment for Evidence‐based Medicine and Evaluation Danube University Krems Krems AustriaSonghor Healthcare Center Kermanshah University of Medical Sciences Kermanshah IranAbstract Coronavirus disease (COVID‐19) affects both the respiratory system and the body as a whole. Natural molecules, such as flavonoid quercetin, as potential treatment methods to help patients combat COVID‐19. The aim of this systematic review and meta‐analysis is to give a comprehensive overview of the impact of quercetin supplementation on inflammatory factors, hospital admission, and mortality of patients with COVID‐19. The search has been conducted on PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library using relevant keywords until August 25, 2023. We included randomized controlled trials (RCTs) comparing COVID‐19 patients who received quercetin supplementation versus controls. We included five studies summarizing the evidence in 544 patients. Meta‐analysis showed that quercetin administration significantly reduced LDH activity (standard mean difference (SMD): −0.42, 95% CI: −0.82, −0.02, I2 = 48.86%), decreased the risk of hospital admission by 70% (RR: 0.30, 95% CI: 0.14, 0.62, I2 = 00.00%), ICU admission by 73% (RR: 0.27, 95% CI: 0.09, 0.78, I2 = 20.66%), and mortality by 82% (RR: 0.18, 95% CI: 0.03, 0.98, I2 = 00.00%). No significant changes in CRP, D‐dimmer, and ferritin were found between groups. Quercetin was found to significantly reduce LDH levels and decrease the risk of hospital and ICU admission and mortality in patients with COVID‐19 infection.https://doi.org/10.1002/fsn3.3715COVID‐19CRPD‐dimmerferritinLDHmortality |
| spellingShingle | Somayeh Ziaei Malek Alimohammadi‐Kamalabadi Motahareh Hasani Mahsa Malekahmadi Emma Persad Javad Heshmati The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis Food Science & Nutrition COVID‐19 CRP D‐dimmer ferritin LDH mortality |
| title | The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis |
| title_full | The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis |
| title_fullStr | The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis |
| title_full_unstemmed | The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis |
| title_short | The effect of quercetin supplementation on clinical outcomes in COVID‐19 patients: A systematic review and meta‐analysis |
| title_sort | effect of quercetin supplementation on clinical outcomes in covid 19 patients a systematic review and meta analysis |
| topic | COVID‐19 CRP D‐dimmer ferritin LDH mortality |
| url | https://doi.org/10.1002/fsn3.3715 |
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