Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas
Somatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14701-6 |
| _version_ | 1818570992929210368 |
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| author | Mthabisi B. Moyo J. Brandon Parker Debabrata Chakravarti |
| author_facet | Mthabisi B. Moyo J. Brandon Parker Debabrata Chakravarti |
| author_sort | Mthabisi B. Moyo |
| collection | DOAJ |
| description | Somatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differential enhancer usage and transcription factor AP-1 occupancy are significant drivers of transcriptional dysregulation in MED12 mutant leiomyomas. |
| first_indexed | 2024-12-14T13:49:37Z |
| format | Article |
| id | doaj.art-a01835de97ba44deb1d5266b194a1767 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:49:37Z |
| publishDate | 2020-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a01835de97ba44deb1d5266b194a17672022-12-21T22:59:11ZengNature PortfolioNature Communications2041-17232020-02-0111111610.1038/s41467-020-14701-6Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomasMthabisi B. Moyo0J. Brandon Parker1Debabrata Chakravarti2Driskill Graduate Program in Life Sciences, Feinberg School of Medicine, Northwestern UniversityDepartment of Obstetrics and Gynecology, Division of Reproductive Science in Medicine, Feinberg School of Medicine, Northwestern UniversityDepartment of Obstetrics and Gynecology, Division of Reproductive Science in Medicine, Feinberg School of Medicine, Northwestern UniversitySomatic mutations in MED12 have been implicated as the causal genetic lesion in the majority of uterine leiomyomas. Here, the authors profile the chromatin landscape of matched normal and leiomyoma tissues and find that changes in enhancer acetylation, enhancer-promoter interaction strength, differential enhancer usage and transcription factor AP-1 occupancy are significant drivers of transcriptional dysregulation in MED12 mutant leiomyomas.https://doi.org/10.1038/s41467-020-14701-6 |
| spellingShingle | Mthabisi B. Moyo J. Brandon Parker Debabrata Chakravarti Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas Nature Communications |
| title | Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas |
| title_full | Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas |
| title_fullStr | Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas |
| title_full_unstemmed | Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas |
| title_short | Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas |
| title_sort | altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in med12 mutant uterine leiomyomas |
| url | https://doi.org/10.1038/s41467-020-14701-6 |
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