Live Imaging of Innate and Adaptive Immune Responses in the Liver
Immune response in the liver is determined by the spatial organization and cellular dynamics of hepatic immune cells. The liver vasculature accommodates abundant tissue-resident innate immune cells, such as Kupffer cells, natural killer cells, and natural killer T cells, to ensure efficient intravas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.564768/full |
| _version_ | 1818187836332965888 |
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| author | Lu Li Lu Li Zhutian Zeng Zhutian Zeng |
| author_facet | Lu Li Lu Li Zhutian Zeng Zhutian Zeng |
| author_sort | Lu Li |
| collection | DOAJ |
| description | Immune response in the liver is determined by the spatial organization and cellular dynamics of hepatic immune cells. The liver vasculature accommodates abundant tissue-resident innate immune cells, such as Kupffer cells, natural killer cells, and natural killer T cells, to ensure efficient intravascular immunosurveillance. The fenestrated sinusoids also allow direct contact between circulating T cells and non-canonical antigen-presenting cells, such as hepatocytes, to instruct adaptive immune responses. Distinct cellular behaviors are exploited by liver immune cells to exert proper functions. Intravital imaging enables real-time visualization of individual immune cell in living animals, representing a powerful tool in dissecting the spatiotemporal features of intrahepatic immune cells during steady state and liver diseases. This review summarizes current advances in liver immunology prompted by in vivo imaging, with a particular focus on liver-resident innate immune cells and hepatic T cells. |
| first_indexed | 2024-12-11T23:17:21Z |
| format | Article |
| id | doaj.art-a01b826e20ea4637a0103dd60689903c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T23:17:21Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a01b826e20ea4637a0103dd60689903c2022-12-22T00:46:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.564768564768Live Imaging of Innate and Adaptive Immune Responses in the LiverLu Li0Lu Li1Zhutian Zeng2Zhutian Zeng3The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaHefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaImmune response in the liver is determined by the spatial organization and cellular dynamics of hepatic immune cells. The liver vasculature accommodates abundant tissue-resident innate immune cells, such as Kupffer cells, natural killer cells, and natural killer T cells, to ensure efficient intravascular immunosurveillance. The fenestrated sinusoids also allow direct contact between circulating T cells and non-canonical antigen-presenting cells, such as hepatocytes, to instruct adaptive immune responses. Distinct cellular behaviors are exploited by liver immune cells to exert proper functions. Intravital imaging enables real-time visualization of individual immune cell in living animals, representing a powerful tool in dissecting the spatiotemporal features of intrahepatic immune cells during steady state and liver diseases. This review summarizes current advances in liver immunology prompted by in vivo imaging, with a particular focus on liver-resident innate immune cells and hepatic T cells.https://www.frontiersin.org/article/10.3389/fimmu.2020.564768/fullintravital imagingKupffer celliNKT cellNK cellT cellsinfection |
| spellingShingle | Lu Li Lu Li Zhutian Zeng Zhutian Zeng Live Imaging of Innate and Adaptive Immune Responses in the Liver Frontiers in Immunology intravital imaging Kupffer cell iNKT cell NK cell T cells infection |
| title | Live Imaging of Innate and Adaptive Immune Responses in the Liver |
| title_full | Live Imaging of Innate and Adaptive Immune Responses in the Liver |
| title_fullStr | Live Imaging of Innate and Adaptive Immune Responses in the Liver |
| title_full_unstemmed | Live Imaging of Innate and Adaptive Immune Responses in the Liver |
| title_short | Live Imaging of Innate and Adaptive Immune Responses in the Liver |
| title_sort | live imaging of innate and adaptive immune responses in the liver |
| topic | intravital imaging Kupffer cell iNKT cell NK cell T cells infection |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.564768/full |
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