Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province
Abstract Liver cancer, a chronic non-communicable disease, represents a serious public health problem. Long-term trends in the burden of liver cancer disease are heterogeneous across regions. Incidence and mortality of liver cancer, based on the Global Burden of Disease, were collected from the Chin...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-53812-8 |
| _version_ | 1797274947456860160 |
|---|---|
| author | Hao Liu Jun Li Shijie Zhu Xupeng Zhang Faxue Zhang Xiaowei Zhang Gaichan Zhao Wei Zhu Fang Zhou |
| author_facet | Hao Liu Jun Li Shijie Zhu Xupeng Zhang Faxue Zhang Xiaowei Zhang Gaichan Zhao Wei Zhu Fang Zhou |
| author_sort | Hao Liu |
| collection | DOAJ |
| description | Abstract Liver cancer, a chronic non-communicable disease, represents a serious public health problem. Long-term trends in the burden of liver cancer disease are heterogeneous across regions. Incidence and mortality of liver cancer, based on the Global Burden of Disease, were collected from the Chinese Centre for Disease Control and Prevention. Age–period–cohort model was utilized to reveal the secular trends and estimate the age, period and cohort effects on primary liver cancer due to specific etiologies. Both the age-standardized incidence and mortality rate of liver cancer in Hubei province were on the rise, although there were discrepancies between gender groups. From age–period–cohort analysis, both incidence and mortality of liver cancer due to Hepatitis B virus were the highest in all age groups. The incidence of all liver cancer groups increased with time period in males, while this upward trend was observed in females only in liver cancer due to alcohol use group. Cohort effects indicated the disease burden of liver cancer decreased with birth cohorts. Local drifts showed that the incidence of liver cancer due to specific etiologies was increasing in the age group of males between 40 and 75 years old. The impact of an aging population will continue in Hubei Province. the disease burden of liver cancer will continue to increase, and personalized prevention policies must be adopted to address these changes. |
| first_indexed | 2024-03-07T15:07:26Z |
| format | Article |
| id | doaj.art-a01ccce8c01943878936510d71db79e4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:07:26Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a01ccce8c01943878936510d71db79e42024-03-05T18:52:32ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-53812-8Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei ProvinceHao Liu0Jun Li1Shijie Zhu2Xupeng Zhang3Faxue Zhang4Xiaowei Zhang5Gaichan Zhao6Wei Zhu7Fang Zhou8Institute of Chronic Disease Prevention and Cure, Hubei Provincial Center for Disease Control and PreventionInstitute of Health Inspection and Testing, Hubei Provincial Center for Disease Control and PreventionDepartment of Occupational and Environmental Health, School of Public Health, Wuhan UniversityWuhan Changjiang New Area Center for Disease Control and PreventionDepartment of Occupational and Environmental Health, School of Public Health, Wuhan UniversityDepartment of Occupational and Environmental Health, School of Public Health, Wuhan UniversityDepartment of Public Health, School of Public Health, Wuhan UniversityDepartment of Occupational and Environmental Health, School of Public Health, Wuhan UniversityInstitute of Chronic Disease Prevention and Cure, Hubei Provincial Center for Disease Control and PreventionAbstract Liver cancer, a chronic non-communicable disease, represents a serious public health problem. Long-term trends in the burden of liver cancer disease are heterogeneous across regions. Incidence and mortality of liver cancer, based on the Global Burden of Disease, were collected from the Chinese Centre for Disease Control and Prevention. Age–period–cohort model was utilized to reveal the secular trends and estimate the age, period and cohort effects on primary liver cancer due to specific etiologies. Both the age-standardized incidence and mortality rate of liver cancer in Hubei province were on the rise, although there were discrepancies between gender groups. From age–period–cohort analysis, both incidence and mortality of liver cancer due to Hepatitis B virus were the highest in all age groups. The incidence of all liver cancer groups increased with time period in males, while this upward trend was observed in females only in liver cancer due to alcohol use group. Cohort effects indicated the disease burden of liver cancer decreased with birth cohorts. Local drifts showed that the incidence of liver cancer due to specific etiologies was increasing in the age group of males between 40 and 75 years old. The impact of an aging population will continue in Hubei Province. the disease burden of liver cancer will continue to increase, and personalized prevention policies must be adopted to address these changes.https://doi.org/10.1038/s41598-024-53812-8Age–period–cohort analysisLiver cancerIncidenceMortalityHepatitis virus |
| spellingShingle | Hao Liu Jun Li Shijie Zhu Xupeng Zhang Faxue Zhang Xiaowei Zhang Gaichan Zhao Wei Zhu Fang Zhou Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province Scientific Reports Age–period–cohort analysis Liver cancer Incidence Mortality Hepatitis virus |
| title | Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province |
| title_full | Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province |
| title_fullStr | Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province |
| title_full_unstemmed | Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province |
| title_short | Long-term trends in incidence, mortality and burden of liver cancer due to specific etiologies in Hubei Province |
| title_sort | long term trends in incidence mortality and burden of liver cancer due to specific etiologies in hubei province |
| topic | Age–period–cohort analysis Liver cancer Incidence Mortality Hepatitis virus |
| url | https://doi.org/10.1038/s41598-024-53812-8 |
| work_keys_str_mv | AT haoliu longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT junli longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT shijiezhu longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT xupengzhang longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT faxuezhang longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT xiaoweizhang longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT gaichanzhao longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT weizhu longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince AT fangzhou longtermtrendsinincidencemortalityandburdenoflivercancerduetospecificetiologiesinhubeiprovince |