Structural and functional connectivity in traumatic brain injury
Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms. However, the neurobiological mechanisms underlying specific impairments are not fully understood. Advances in neuroimaging techniques (such as diffusion tensor imaging and functional MRI) have given u...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=12;spage=2062;epage=2071;aulast=Xiao |
| _version_ | 1819071784335441920 |
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| author | Hui Xiao Yang Yang Ji-hui Xi Zi-qian Chen |
| author_facet | Hui Xiao Yang Yang Ji-hui Xi Zi-qian Chen |
| author_sort | Hui Xiao |
| collection | DOAJ |
| description | Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms. However, the neurobiological mechanisms underlying specific impairments are not fully understood. Advances in neuroimaging techniques (such as diffusion tensor imaging and functional MRI) have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease. The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks. Using these powerful neuroimaging approaches, changes at the microstructural level can be detected through regional and global properties of neuronal networks. Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury, mainly focusing on structural and functional connectivity. Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury. These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae, as well as predicting outcome and prognosis. |
| first_indexed | 2024-12-21T17:27:20Z |
| format | Article |
| id | doaj.art-a01d10b042544bccb655143afa11b001 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-21T17:27:20Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-a01d10b042544bccb655143afa11b0012022-12-21T18:56:01ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110122062207110.4103/1673-5374.172328Structural and functional connectivity in traumatic brain injuryHui XiaoYang YangJi-hui XiZi-qian ChenTraumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms. However, the neurobiological mechanisms underlying specific impairments are not fully understood. Advances in neuroimaging techniques (such as diffusion tensor imaging and functional MRI) have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease. The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks. Using these powerful neuroimaging approaches, changes at the microstructural level can be detected through regional and global properties of neuronal networks. Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury, mainly focusing on structural and functional connectivity. Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury. These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae, as well as predicting outcome and prognosis.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=12;spage=2062;epage=2071;aulast=Xiaonerve regeneration; traumatic brain injury; brain trauma; connectivity; diffusion tensor imaging; resting-state fMRI; connectome; default mode network; cognition; neural regeneration |
| spellingShingle | Hui Xiao Yang Yang Ji-hui Xi Zi-qian Chen Structural and functional connectivity in traumatic brain injury Neural Regeneration Research nerve regeneration; traumatic brain injury; brain trauma; connectivity; diffusion tensor imaging; resting-state fMRI; connectome; default mode network; cognition; neural regeneration |
| title | Structural and functional connectivity in traumatic brain injury |
| title_full | Structural and functional connectivity in traumatic brain injury |
| title_fullStr | Structural and functional connectivity in traumatic brain injury |
| title_full_unstemmed | Structural and functional connectivity in traumatic brain injury |
| title_short | Structural and functional connectivity in traumatic brain injury |
| title_sort | structural and functional connectivity in traumatic brain injury |
| topic | nerve regeneration; traumatic brain injury; brain trauma; connectivity; diffusion tensor imaging; resting-state fMRI; connectome; default mode network; cognition; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=12;spage=2062;epage=2071;aulast=Xiao |
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