NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 mus...

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Bibliographic Details
Main Authors: Dalei Wu, Xiaoyu Su, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
PAS domains
Neuronal PAS Proteins
bHLH-PAS proteins
ligand binding pockets
crystal structure
psychiatric disorders
Online Access:https://elifesciences.org/articles/18790

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