Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats
Introduction: Organophosphorus (OPs) pesticides such as malathion intoxication has been shown to generate oxidative stress due to the production of free radicals and alteration of the antioxidant defense system. The aim of this study was to evaluate the effects of extracts from green tea (GT) hydroa...
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Shahrekord University of Medical Sciences
2016-07-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | http://herbmedpharmacol.com/PDF/JHP_1012_20160131134846 |
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| author | Negar Mehri Hamed Felehgari Amir Larki Harchegani Hamid Behrooj Nejat Kheiripour Hassan Ghasemi Mahmoud Mirhoseini Akram Ranjbar |
| author_facet | Negar Mehri Hamed Felehgari Amir Larki Harchegani Hamid Behrooj Nejat Kheiripour Hassan Ghasemi Mahmoud Mirhoseini Akram Ranjbar |
| author_sort | Negar Mehri |
| collection | DOAJ |
| description | Introduction: Organophosphorus (OPs) pesticides such as malathion intoxication has been shown to generate oxidative stress due to the production of free radicals and alteration of the antioxidant defense system. The aim of this study was to evaluate the effects of extracts from green tea (GT) hydroalcoholic extract on liver function. Methods: Male Wistar rats were separated into 4 groups of 8 rats each. Group I (control), group II was given GT (10 mg/kg/day). Animals of groups III received only malathion, group IV was given GT+ malathion. Animals received malathion 150 mg/kg by gavage and GT 30 mg/kg for 1 week through intraperitoneal injection. Twenty-four hours after treatment, blood samples were collected. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) concentrations as well as biomarkers of oxidative stress such as lipid peroxidation (LPO), total antioxidant capacity (TAC) and total thiol groups (TTG) were measured. Results: A decrease in ALT and AST levels in GT group were observed compared with the ones in control group. Also, the results showed that malathion could increase liver toxicity in rats through reduction of ALT and AST. Conclusion: Amelioration of malathion toxicity through reduction of inflammation may suggest a prolonged therapeutic option against pesticides-induced hepatotoxicity. |
| first_indexed | 2024-12-13T05:07:36Z |
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| id | doaj.art-a01d44f5f1fe497b946f42b8312720bf |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-12-13T05:07:36Z |
| publishDate | 2016-07-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-a01d44f5f1fe497b946f42b8312720bf2022-12-21T23:58:38ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042016-07-0153116119JHP_1012_20160131134846Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in ratsNegar Mehri0Hamed Felehgari1Amir Larki Harchegani2Hamid Behrooj3Nejat Kheiripour4Hassan Ghasemi5Mahmoud Mirhoseini6Akram Ranjbar7Student Research Center, Hamadan University of Medical Sciences, Hamadan, IranStudent Research Center, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranStudent Research Center, Hamadan University of Medical Sciences, Hamadan, IranStudent Research Center, Hamadan University of Medical Sciences, Hamadan, IranAbadan school of Medical Sciences, Abadan, IranMedical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, IranIntroduction: Organophosphorus (OPs) pesticides such as malathion intoxication has been shown to generate oxidative stress due to the production of free radicals and alteration of the antioxidant defense system. The aim of this study was to evaluate the effects of extracts from green tea (GT) hydroalcoholic extract on liver function. Methods: Male Wistar rats were separated into 4 groups of 8 rats each. Group I (control), group II was given GT (10 mg/kg/day). Animals of groups III received only malathion, group IV was given GT+ malathion. Animals received malathion 150 mg/kg by gavage and GT 30 mg/kg for 1 week through intraperitoneal injection. Twenty-four hours after treatment, blood samples were collected. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) concentrations as well as biomarkers of oxidative stress such as lipid peroxidation (LPO), total antioxidant capacity (TAC) and total thiol groups (TTG) were measured. Results: A decrease in ALT and AST levels in GT group were observed compared with the ones in control group. Also, the results showed that malathion could increase liver toxicity in rats through reduction of ALT and AST. Conclusion: Amelioration of malathion toxicity through reduction of inflammation may suggest a prolonged therapeutic option against pesticides-induced hepatotoxicity.http://herbmedpharmacol.com/PDF/JHP_1012_20160131134846Green teaMalathionALTASTOxidative toxic stressRat |
| spellingShingle | Negar Mehri Hamed Felehgari Amir Larki Harchegani Hamid Behrooj Nejat Kheiripour Hassan Ghasemi Mahmoud Mirhoseini Akram Ranjbar Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats Journal of HerbMed Pharmacology Green tea Malathion ALT AST Oxidative toxic stress Rat |
| title | Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats |
| title_full | Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats |
| title_fullStr | Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats |
| title_full_unstemmed | Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats |
| title_short | Hepatoprotective effect of the root extract of green tea against malathion-induced oxidative stress in rats |
| title_sort | hepatoprotective effect of the root extract of green tea against malathion induced oxidative stress in rats |
| topic | Green tea Malathion ALT AST Oxidative toxic stress Rat |
| url | http://herbmedpharmacol.com/PDF/JHP_1012_20160131134846 |
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