Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity
Cancer therapy-induced cardiotoxicity (CTIC) is an important cause of death in cancer survivors which often results in the withdrawal or discontinuation of drugs. The underlying mechanisms of CTIC remain unclear. Circular RNAs (circRNAs) are a class of non-coding regulatory RNA molecules which have...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1152436/full |
| _version_ | 1797867192072536064 |
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| author | Ziji Cheng Wanting Qin Shaoling Li Shuijin Shao Baonian Liu |
| author_facet | Ziji Cheng Wanting Qin Shaoling Li Shuijin Shao Baonian Liu |
| author_sort | Ziji Cheng |
| collection | DOAJ |
| description | Cancer therapy-induced cardiotoxicity (CTIC) is an important cause of death in cancer survivors which often results in the withdrawal or discontinuation of drugs. The underlying mechanisms of CTIC remain unclear. Circular RNAs (circRNAs) are a class of non-coding regulatory RNA molecules which have emerged in recent years. They are generated by back splicing and have powerful biological functions, including transcription and splicing, isolating or building macromolecular scaffolds to interfere with microRNA activity and signaling pathways, and acting as templates for translation. Moreover, circRNAs demonstrate high abundance and significant stability. CircRNAs can be used as novel biomarkers because they often function in a cell-type and tissue-specific manner. CircRNAs have attracted increasing attention in cardiovascular disease research, and recent studies exploring the role of circRNAs in CTIC have had promising results. This review will summarize the current understanding of circRNAs’ biogenesis, regulation and function. Their clinical potential as biomarkers, therapeutic agents and drug targets will also be explored. |
| first_indexed | 2024-04-09T23:37:28Z |
| format | Article |
| id | doaj.art-a01d80c63b12459cb1185567623ca6f2 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T23:37:28Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-a01d80c63b12459cb1185567623ca6f22023-03-20T05:46:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.11524361152436Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicityZiji Cheng0Wanting Qin1Shaoling Li2Shuijin Shao3Baonian Liu4Department of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pathology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Anatomy, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer therapy-induced cardiotoxicity (CTIC) is an important cause of death in cancer survivors which often results in the withdrawal or discontinuation of drugs. The underlying mechanisms of CTIC remain unclear. Circular RNAs (circRNAs) are a class of non-coding regulatory RNA molecules which have emerged in recent years. They are generated by back splicing and have powerful biological functions, including transcription and splicing, isolating or building macromolecular scaffolds to interfere with microRNA activity and signaling pathways, and acting as templates for translation. Moreover, circRNAs demonstrate high abundance and significant stability. CircRNAs can be used as novel biomarkers because they often function in a cell-type and tissue-specific manner. CircRNAs have attracted increasing attention in cardiovascular disease research, and recent studies exploring the role of circRNAs in CTIC have had promising results. This review will summarize the current understanding of circRNAs’ biogenesis, regulation and function. Their clinical potential as biomarkers, therapeutic agents and drug targets will also be explored.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1152436/fullbiomakercircRNAdoxorubicintherapeutic targetcancer therapy-induced cardiotoxicity |
| spellingShingle | Ziji Cheng Wanting Qin Shaoling Li Shuijin Shao Baonian Liu Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity Frontiers in Cardiovascular Medicine biomaker circRNA doxorubicin therapeutic target cancer therapy-induced cardiotoxicity |
| title | Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity |
| title_full | Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity |
| title_fullStr | Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity |
| title_full_unstemmed | Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity |
| title_short | Emerging roles of circular RNAs in cancer therapy-induced cardiotoxicity |
| title_sort | emerging roles of circular rnas in cancer therapy induced cardiotoxicity |
| topic | biomaker circRNA doxorubicin therapeutic target cancer therapy-induced cardiotoxicity |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1152436/full |
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