Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?
In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that parallels the increased prevalence of obesity and which markedly increases the risk of cardiovascular disease across the globe. While ischemic heart disease represents the major cause of death in diabetic sub...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/17/12/2136 |
| _version_ | 1811314809481723904 |
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| author | Maximilian E. Hölscher Christoph Bode Heiko Bugger |
| author_facet | Maximilian E. Hölscher Christoph Bode Heiko Bugger |
| author_sort | Maximilian E. Hölscher |
| collection | DOAJ |
| description | In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that parallels the increased prevalence of obesity and which markedly increases the risk of cardiovascular disease across the globe. While ischemic heart disease represents the major cause of death in diabetic subjects, diabetic cardiomyopathy (DC) summarizes adverse effects of diabetes mellitus on the heart that are independent of coronary artery disease (CAD) and hypertension. DC increases the risk of heart failure (HF) and may lead to both heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie DC that partially overlap with mechanisms believed to contribute to heart failure. Nevertheless, the existence of DC remains a topic of controversy, although the clinical relevance of DC is increasingly recognized by scientists and clinicians. In addition, relatively little attention has been attributed to the fact that both underlying mechanisms and clinical features of DC may be partially distinct in type 1 versus type 2 diabetes. In the following review, we will discuss clinical and preclinical literature on the existence of human DC in the context of the two different types of diabetes mellitus. |
| first_indexed | 2024-04-13T11:19:06Z |
| format | Article |
| id | doaj.art-a01e840b12154c84b6d60cb05862ba9b |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T11:19:06Z |
| publishDate | 2016-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a01e840b12154c84b6d60cb05862ba9b2022-12-22T02:48:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-12-011712213610.3390/ijms17122136ijms17122136Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?Maximilian E. Hölscher0Christoph Bode1Heiko Bugger2Cardiology and Angiology I, University Heart Center Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyCardiology and Angiology I, University Heart Center Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyCardiology and Angiology I, University Heart Center Freiburg, Hugstetter Str. 55, 79106 Freiburg, GermanyIn recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that parallels the increased prevalence of obesity and which markedly increases the risk of cardiovascular disease across the globe. While ischemic heart disease represents the major cause of death in diabetic subjects, diabetic cardiomyopathy (DC) summarizes adverse effects of diabetes mellitus on the heart that are independent of coronary artery disease (CAD) and hypertension. DC increases the risk of heart failure (HF) and may lead to both heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie DC that partially overlap with mechanisms believed to contribute to heart failure. Nevertheless, the existence of DC remains a topic of controversy, although the clinical relevance of DC is increasingly recognized by scientists and clinicians. In addition, relatively little attention has been attributed to the fact that both underlying mechanisms and clinical features of DC may be partially distinct in type 1 versus type 2 diabetes. In the following review, we will discuss clinical and preclinical literature on the existence of human DC in the context of the two different types of diabetes mellitus.http://www.mdpi.com/1422-0067/17/12/2136diabetic cardiomyopathyheartdiabetes mellitus |
| spellingShingle | Maximilian E. Hölscher Christoph Bode Heiko Bugger Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? International Journal of Molecular Sciences diabetic cardiomyopathy heart diabetes mellitus |
| title | Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? |
| title_full | Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? |
| title_fullStr | Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? |
| title_full_unstemmed | Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? |
| title_short | Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? |
| title_sort | diabetic cardiomyopathy does the type of diabetes matter |
| topic | diabetic cardiomyopathy heart diabetes mellitus |
| url | http://www.mdpi.com/1422-0067/17/12/2136 |
| work_keys_str_mv | AT maximilianeholscher diabeticcardiomyopathydoesthetypeofdiabetesmatter AT christophbode diabeticcardiomyopathydoesthetypeofdiabetesmatter AT heikobugger diabeticcardiomyopathydoesthetypeofdiabetesmatter |