Dashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curves
Abstract Background Recording and analyzing microbial growth is a routine task in the life sciences. Microplate readers that record dozens to hundreds of growth curves simultaneously are increasingly used for this task raising the demand for their rapid and reliable analysis. Results Here, we presen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12859-024-05692-y |
| _version_ | 1797273050921566208 |
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| author | Michael A. Reiter Julia A. Vorholt |
| author_facet | Michael A. Reiter Julia A. Vorholt |
| author_sort | Michael A. Reiter |
| collection | DOAJ |
| description | Abstract Background Recording and analyzing microbial growth is a routine task in the life sciences. Microplate readers that record dozens to hundreds of growth curves simultaneously are increasingly used for this task raising the demand for their rapid and reliable analysis. Results Here, we present Dashing Growth Curves, an interactive web application ( http://dashing-growth-curves.ethz.ch/ ) that enables researchers to quickly visualize and analyze growth curves without the requirement for coding knowledge and independent of operating system. Growth curves can be fitted with parametric and non-parametric models or manually. The application extracts maximum growth rates as well as other features such as lag time, length of exponential growth phase and maximum population size among others. Furthermore, Dashing Growth Curves automatically groups replicate samples and generates downloadable summary plots for of all growth parameters. Conclusions Dashing Growth Curves is an open-source web application that reduces the time required to analyze microbial growth curves from hours to minutes. |
| first_indexed | 2024-03-07T14:37:58Z |
| format | Article |
| id | doaj.art-a022bdccaf2c4a809674c0a79133b60e |
| institution | Directory Open Access Journal |
| issn | 1471-2105 |
| language | English |
| last_indexed | 2024-03-07T14:37:58Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Bioinformatics |
| spelling | doaj.art-a022bdccaf2c4a809674c0a79133b60e2024-03-05T20:31:59ZengBMCBMC Bioinformatics1471-21052024-02-012511910.1186/s12859-024-05692-yDashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curvesMichael A. Reiter0Julia A. Vorholt1Department of Biology, Institute of Microbiology, ETH ZurichDepartment of Biology, Institute of Microbiology, ETH ZurichAbstract Background Recording and analyzing microbial growth is a routine task in the life sciences. Microplate readers that record dozens to hundreds of growth curves simultaneously are increasingly used for this task raising the demand for their rapid and reliable analysis. Results Here, we present Dashing Growth Curves, an interactive web application ( http://dashing-growth-curves.ethz.ch/ ) that enables researchers to quickly visualize and analyze growth curves without the requirement for coding knowledge and independent of operating system. Growth curves can be fitted with parametric and non-parametric models or manually. The application extracts maximum growth rates as well as other features such as lag time, length of exponential growth phase and maximum population size among others. Furthermore, Dashing Growth Curves automatically groups replicate samples and generates downloadable summary plots for of all growth parameters. Conclusions Dashing Growth Curves is an open-source web application that reduces the time required to analyze microbial growth curves from hours to minutes.https://doi.org/10.1186/s12859-024-05692-yAutomationGrowth curveGompertzLogisticWeb applicationOpen source |
| spellingShingle | Michael A. Reiter Julia A. Vorholt Dashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curves BMC Bioinformatics Automation Growth curve Gompertz Logistic Web application Open source |
| title | Dashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curves |
| title_full | Dashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curves |
| title_fullStr | Dashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curves |
| title_full_unstemmed | Dashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curves |
| title_short | Dashing Growth Curves: a web application for rapid and interactive analysis of microbial growth curves |
| title_sort | dashing growth curves a web application for rapid and interactive analysis of microbial growth curves |
| topic | Automation Growth curve Gompertz Logistic Web application Open source |
| url | https://doi.org/10.1186/s12859-024-05692-y |
| work_keys_str_mv | AT michaelareiter dashinggrowthcurvesawebapplicationforrapidandinteractiveanalysisofmicrobialgrowthcurves AT juliaavorholt dashinggrowthcurvesawebapplicationforrapidandinteractiveanalysisofmicrobialgrowthcurves |