Novel Insights Into Leishmania (Viannia) braziliensis In Vitro Fitness Guided by Temperature Changes Along With Its Subtilisins and Oligopeptidase B

Novel Insights Into Leishmania (Viannia) braziliensis In Vitro Fitness Guided by Temperature Changes Along With Its Subtilisins and Oligopeptidase B

Proteases are virulence factors with a recognized impact on the Leishmania spp. life cycle. This study considers a set of analyses measuring phenotypic factors of L. (V.) braziliensis clinical isolates as promastigotes growth curves, murine peritoneal macrophages infection, inflammatory mediators pr...

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Bibliographic Details
Main Authors: Anabel Zabala-Peñafiel, Lea Cysne-Finkelstein, Fatima Conceição-Silva, Aline Fagundes, Luciana de Freitas Campos Miranda, Franklin Souza-Silva, Artur A. M. L. Brandt, Geovane Dias-Lopes, Carlos Roberto Alves
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leishmania (Viannia) braziliensis
phenotypic characteristics
gene expression
serine proteases
molecular dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.805106/full

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