Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects
Plant sterols (PS) lower LDL-cholesterol, an established risk factor for CHD. Endothelial dysfunction and low-grade inflammation are two important features in the development of atherosclerosis. Whether PS affect biomarkers of endothelial function and low-grade inflammation is not well studied. The...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2016-01-01
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| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679016000409/type/journal_article |
| _version_ | 1811155930727841792 |
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| author | R. T. Ras D. Fuchs W. P. Koppenol C. G. Schalkwijk A. Otten-Hofman U. Garczarek A. Greyling F. Wagner E. A. Trautwein |
| author_facet | R. T. Ras D. Fuchs W. P. Koppenol C. G. Schalkwijk A. Otten-Hofman U. Garczarek A. Greyling F. Wagner E. A. Trautwein |
| author_sort | R. T. Ras |
| collection | DOAJ |
| description | Plant sterols (PS) lower LDL-cholesterol, an established risk factor for CHD. Endothelial dysfunction and low-grade inflammation are two important features in the development of atherosclerosis. Whether PS affect biomarkers of endothelial function and low-grade inflammation is not well studied. The aim of the present study was to investigate the effect of regular intake of PS on biomarkers of endothelial dysfunction and low-grade inflammation. In a double-blind, randomised, placebo-controlled, parallel-group study, which was primarily designed to investigate the effect of PS intake on vascular function (clinicaltrials.gov: NCT01803178), 240 hypercholesterolaemic but otherwise healthy men and women consumed a low-fat spread with added PS (3 g/d) or a placebo spread for 12 weeks. Endothelial dysfunction biomarkers (both vascular and intracellular adhesion molecules 1 and soluble endothelial-selectin) and low-grade inflammation biomarkers (C-reactive protein, serum amyloid A, IL-6, IL-8, TNF-α and soluble intercellular adhesion molecule-1) were measured using a multi-array detection system based on electrochemiluminescence technology. Biomarkers were combined using z-scores. Differences in changes from baseline between the PS and the placebo groups were assessed. The intake of PS did not significantly change the individual biomarkers of endothelial dysfunction and low-grade inflammation. The z-scores for endothelial dysfunction (−0·02; 95 % CI −0·15, 0·11) and low-grade inflammation (−0·04; 95 % CI −0·16, 0·07) were also not significantly changed after PS intake compared with placebo. In conclusion, biomarkers of endothelial dysfunction and low-grade inflammation were not affected by regular intake of 3 g/d PS for 12 weeks in hypercholesterolaemic men and women. |
| first_indexed | 2024-04-10T04:43:10Z |
| format | Article |
| id | doaj.art-a02351b8ba6f437b9e0c3f1e0ac409cd |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:43:10Z |
| publishDate | 2016-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-a02351b8ba6f437b9e0c3f1e0ac409cd2023-03-09T12:38:49ZengCambridge University PressJournal of Nutritional Science2048-67902016-01-01510.1017/jns.2016.40Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjectsR. T. Ras0D. Fuchs1W. P. Koppenol2C. G. Schalkwijk3A. Otten-Hofman4U. Garczarek5A. Greyling6F. Wagner7E. A. Trautwein8Unilever Research and Development Vlaardingen, Vlaardingen, The NetherlandsUnilever Research and Development Vlaardingen, Vlaardingen, The NetherlandsUnilever Research and Development Vlaardingen, Vlaardingen, The NetherlandsMaastricht University Medical Centre, Maastricht, The NetherlandsUnilever Research and Development Vlaardingen, Vlaardingen, The NetherlandsUnilever Research and Development Vlaardingen, Vlaardingen, The NetherlandsUnilever Research and Development Vlaardingen, Vlaardingen, The NetherlandsCharité Research Organisation, Berlin, GermanyUnilever Research and Development Vlaardingen, Vlaardingen, The NetherlandsPlant sterols (PS) lower LDL-cholesterol, an established risk factor for CHD. Endothelial dysfunction and low-grade inflammation are two important features in the development of atherosclerosis. Whether PS affect biomarkers of endothelial function and low-grade inflammation is not well studied. The aim of the present study was to investigate the effect of regular intake of PS on biomarkers of endothelial dysfunction and low-grade inflammation. In a double-blind, randomised, placebo-controlled, parallel-group study, which was primarily designed to investigate the effect of PS intake on vascular function (clinicaltrials.gov: NCT01803178), 240 hypercholesterolaemic but otherwise healthy men and women consumed a low-fat spread with added PS (3 g/d) or a placebo spread for 12 weeks. Endothelial dysfunction biomarkers (both vascular and intracellular adhesion molecules 1 and soluble endothelial-selectin) and low-grade inflammation biomarkers (C-reactive protein, serum amyloid A, IL-6, IL-8, TNF-α and soluble intercellular adhesion molecule-1) were measured using a multi-array detection system based on electrochemiluminescence technology. Biomarkers were combined using z-scores. Differences in changes from baseline between the PS and the placebo groups were assessed. The intake of PS did not significantly change the individual biomarkers of endothelial dysfunction and low-grade inflammation. The z-scores for endothelial dysfunction (−0·02; 95 % CI −0·15, 0·11) and low-grade inflammation (−0·04; 95 % CI −0·16, 0·07) were also not significantly changed after PS intake compared with placebo. In conclusion, biomarkers of endothelial dysfunction and low-grade inflammation were not affected by regular intake of 3 g/d PS for 12 weeks in hypercholesterolaemic men and women.https://www.cambridge.org/core/product/identifier/S2048679016000409/type/journal_articlePlant sterolsLow-grade inflammationEndothelial dysfunctionDietary interventions |
| spellingShingle | R. T. Ras D. Fuchs W. P. Koppenol C. G. Schalkwijk A. Otten-Hofman U. Garczarek A. Greyling F. Wagner E. A. Trautwein Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects Journal of Nutritional Science Plant sterols Low-grade inflammation Endothelial dysfunction Dietary interventions |
| title | Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects |
| title_full | Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects |
| title_fullStr | Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects |
| title_full_unstemmed | Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects |
| title_short | Effect of a plant sterol-enriched spread on biomarkers of endothelial dysfunction and low-grade inflammation in hypercholesterolaemic subjects |
| title_sort | effect of a plant sterol enriched spread on biomarkers of endothelial dysfunction and low grade inflammation in hypercholesterolaemic subjects |
| topic | Plant sterols Low-grade inflammation Endothelial dysfunction Dietary interventions |
| url | https://www.cambridge.org/core/product/identifier/S2048679016000409/type/journal_article |
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