The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease
Summary: Alzheimer’s disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced ol...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224005029 |
| _version_ | 1797287586387984384 |
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| author | Kefu Liu Ailikemu Aierken Mengyao Liu Nazakat Parhat Wei Kong Xingyu Yin Gang Liu Ding Yu Jie Hong Junjun Ni Zhenzhen Quan Xiaoyun Liu Simei Ji Jian Mao Weijun Peng Chao Chen Yan Yan Hong Qing |
| author_facet | Kefu Liu Ailikemu Aierken Mengyao Liu Nazakat Parhat Wei Kong Xingyu Yin Gang Liu Ding Yu Jie Hong Junjun Ni Zhenzhen Quan Xiaoyun Liu Simei Ji Jian Mao Weijun Peng Chao Chen Yan Yan Hong Qing |
| author_sort | Kefu Liu |
| collection | DOAJ |
| description | Summary: Alzheimer’s disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level. Microglia and astrocyte specific proteins showed strong interactions in the conserved co-expression network module. Moreover, this interaction declines only in mild cognitive impairment patients in human postmortem brain proteomic data. This suggests that astrocytes-microglia interaction may play a leading role in the early stage of Aβ-induced olfactory memory impairment, and the decreasing of their synergy may accelerate the neurodegeneration. |
| first_indexed | 2024-03-07T18:36:24Z |
| format | Article |
| id | doaj.art-a024591bd37744c4bf19b760b87c1385 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-07T18:36:24Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a024591bd37744c4bf19b760b87c13852024-03-02T04:54:39ZengElsevieriScience2589-00422024-03-01273109281The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s diseaseKefu Liu0Ailikemu Aierken1Mengyao Liu2Nazakat Parhat3Wei Kong4Xingyu Yin5Gang Liu6Ding Yu7Jie Hong8Junjun Ni9Zhenzhen Quan10Xiaoyun Liu11Simei Ji12Jian Mao13Weijun Peng14Chao Chen15Yan Yan16Hong Qing17MOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410083, Hunan, China; Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410083, Hunan, China; Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, ChinaKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410083, Hunan, ChinaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, ChinaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, ChinaKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, ChinaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, ChinaDepartment of Biology, Shenzhen MSU-BIT University, Shenzhen 518172, ChinaZhengzhou Tobacco Research Institute of China National Tobacco Company, Zhengzhou 450001, ChinaDepartment of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; National Clinical Research Center for Metabolic Diseases, Changsha, Hunan 410011, ChinaMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410083, Hunan, ChinaDepartment of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China; Corresponding authorKey Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China; Department of Biology, Shenzhen MSU-BIT University, Shenzhen 518172, China; Corresponding authorSummary: Alzheimer’s disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level. Microglia and astrocyte specific proteins showed strong interactions in the conserved co-expression network module. Moreover, this interaction declines only in mild cognitive impairment patients in human postmortem brain proteomic data. This suggests that astrocytes-microglia interaction may play a leading role in the early stage of Aβ-induced olfactory memory impairment, and the decreasing of their synergy may accelerate the neurodegeneration.http://www.sciencedirect.com/science/article/pii/S2589004224005029Classification DescriptionHealth sciencesDiseaseBiological sciences |
| spellingShingle | Kefu Liu Ailikemu Aierken Mengyao Liu Nazakat Parhat Wei Kong Xingyu Yin Gang Liu Ding Yu Jie Hong Junjun Ni Zhenzhen Quan Xiaoyun Liu Simei Ji Jian Mao Weijun Peng Chao Chen Yan Yan Hong Qing The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease iScience Classification Description Health sciences Disease Biological sciences |
| title | The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease |
| title_full | The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease |
| title_fullStr | The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease |
| title_full_unstemmed | The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease |
| title_short | The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease |
| title_sort | decreased astrocyte microglia interaction reflects the early characteristics of alzheimer s disease |
| topic | Classification Description Health sciences Disease Biological sciences |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224005029 |
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