Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application
This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synt...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087621000544 |
| _version_ | 1798035791225552896 |
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| author | Preeti Kush Parveen Kumar Ranjit Singh Ajeet Kaushik |
| author_facet | Preeti Kush Parveen Kumar Ranjit Singh Ajeet Kaushik |
| author_sort | Preeti Kush |
| collection | DOAJ |
| description | This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration. Special insights have been provided on biodistribution, pharmacokinetics, and toxicity in a living system, which is imperative for their wider application in biology. These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging, for example, MRI-CT, MRI-PET. Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body. Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction, heat conduction, imaging, and magnetism. Surely, this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction. |
| first_indexed | 2024-04-11T21:03:10Z |
| format | Article |
| id | doaj.art-a02575324ec246e6aad28750269bc406 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-04-11T21:03:10Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-a02575324ec246e6aad28750269bc4062022-12-22T04:03:25ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762021-11-01166704737Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical applicationPreeti Kush0Parveen Kumar1Ranjit Singh2Ajeet Kaushik3School of Pharmacy, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University Gangoh, Saharanpur, Uttar Pradesh 247341, IndiaNanotechnology Division (H-1), CSIR-Central Scientific Instruments Organization, Chandigarh 160030, India; Corresponding authors.School of Pharmacy, Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University Gangoh, Saharanpur, Uttar Pradesh 247341, IndiaNanoBioTech Laboratory, Health System Engineering, Department of Natural Sciences, Florida Polytechnic University, Lakeland, FL 33805-8531, United States; Corresponding authors.This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration. Special insights have been provided on biodistribution, pharmacokinetics, and toxicity in a living system, which is imperative for their wider application in biology. These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging, for example, MRI-CT, MRI-PET. Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body. Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction, heat conduction, imaging, and magnetism. Surely, this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.http://www.sciencedirect.com/science/article/pii/S1818087621000544MagnetismSynthesisCharacterizationDeliveryImagingBiodistribution |
| spellingShingle | Preeti Kush Parveen Kumar Ranjit Singh Ajeet Kaushik Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application Asian Journal of Pharmaceutical Sciences Magnetism Synthesis Characterization Delivery Imaging Biodistribution |
| title | Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application |
| title_full | Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application |
| title_fullStr | Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application |
| title_full_unstemmed | Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application |
| title_short | Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application |
| title_sort | aspects of high performance and bio acceptable magnetic nanoparticles for biomedical application |
| topic | Magnetism Synthesis Characterization Delivery Imaging Biodistribution |
| url | http://www.sciencedirect.com/science/article/pii/S1818087621000544 |
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