Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis
Objective. The present systematic review and meta-analysis aimed to assess the oxidative stress-mediated lipid peroxidation end product malondialdehyde (MDA) in periodontitis using the available literature. Materials and Methods. An electronic literature search was performed for the published articl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2023/6014706 |
| _version_ | 1797809930867048448 |
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| author | Khadijah Mohideen Krithika Chandrasekar Saranya Ramsridhar Chandini Rajkumar Snehashish Ghosh Safal Dhungel |
| author_facet | Khadijah Mohideen Krithika Chandrasekar Saranya Ramsridhar Chandini Rajkumar Snehashish Ghosh Safal Dhungel |
| author_sort | Khadijah Mohideen |
| collection | DOAJ |
| description | Objective. The present systematic review and meta-analysis aimed to assess the oxidative stress-mediated lipid peroxidation end product malondialdehyde (MDA) in periodontitis using the available literature. Materials and Methods. An electronic literature search was performed for the published articles from 2000 to 2022 in PubMed (MeSH), Science Direct, Wiley Online library, and cross-reference using specific keywords. Results. The literature search identified 1,166 articles. After analyzing the abstracts of the obtained articles, the articles were excluded for the following reasons: duplicate studies (n = 395) and not relevant to the research question (n = 726). The remaining 45 articles were chosen for full-text evaluation. Finally, the present qualitative synthesis selected 34 articles that met the inclusion criteria for evaluation and removed the articles which did not meet the required criteria (n = 11). Out of these, 16 articles had coherent data for quantitative synthesis. The meta-analysis used the standardized mean differences method at a 95% confidence interval by random-effects model. The periodontitis group displayed significantly higher MDA levels (P<0.001) in gingival crevicular fluid, saliva, and serum samples of the studies analyzed than the healthy control. Conclusion. The analyzed studies showed significantly higher MDA levels in various biological samples of patients with periodontitis, supporting the role of elevated oxidative stress and consequent lipid peroxidation in periodontitis. |
| first_indexed | 2024-03-13T07:00:20Z |
| format | Article |
| id | doaj.art-a025c51910c54d15b5e840998a5cac3f |
| institution | Directory Open Access Journal |
| issn | 1687-8736 |
| language | English |
| last_indexed | 2024-03-13T07:00:20Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj.art-a025c51910c54d15b5e840998a5cac3f2023-06-07T00:00:06ZengHindawi LimitedInternational Journal of Dentistry1687-87362023-01-01202310.1155/2023/6014706Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-AnalysisKhadijah Mohideen0Krithika Chandrasekar1Saranya Ramsridhar2Chandini Rajkumar3Snehashish Ghosh4Safal Dhungel5Department of Oral Pathology and MicrobiologyMeenakshi Academy of Higher Education and ResearchDepartment of Oral Pathology and MicrobiologyDepartment of Oral Pathology and MicrobiologyDepartment of Oral PathologyDepartment of Oral and Maxillofacial SurgeryObjective. The present systematic review and meta-analysis aimed to assess the oxidative stress-mediated lipid peroxidation end product malondialdehyde (MDA) in periodontitis using the available literature. Materials and Methods. An electronic literature search was performed for the published articles from 2000 to 2022 in PubMed (MeSH), Science Direct, Wiley Online library, and cross-reference using specific keywords. Results. The literature search identified 1,166 articles. After analyzing the abstracts of the obtained articles, the articles were excluded for the following reasons: duplicate studies (n = 395) and not relevant to the research question (n = 726). The remaining 45 articles were chosen for full-text evaluation. Finally, the present qualitative synthesis selected 34 articles that met the inclusion criteria for evaluation and removed the articles which did not meet the required criteria (n = 11). Out of these, 16 articles had coherent data for quantitative synthesis. The meta-analysis used the standardized mean differences method at a 95% confidence interval by random-effects model. The periodontitis group displayed significantly higher MDA levels (P<0.001) in gingival crevicular fluid, saliva, and serum samples of the studies analyzed than the healthy control. Conclusion. The analyzed studies showed significantly higher MDA levels in various biological samples of patients with periodontitis, supporting the role of elevated oxidative stress and consequent lipid peroxidation in periodontitis.http://dx.doi.org/10.1155/2023/6014706 |
| spellingShingle | Khadijah Mohideen Krithika Chandrasekar Saranya Ramsridhar Chandini Rajkumar Snehashish Ghosh Safal Dhungel Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis International Journal of Dentistry |
| title | Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis |
| title_full | Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis |
| title_fullStr | Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis |
| title_short | Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis |
| title_sort | assessment of oxidative stress by the estimation of lipid peroxidation marker malondialdehyde mda in patients with chronic periodontitis a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2023/6014706 |
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