Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial Paralysis
INTRODUCTION: Bell's palsy, also known as idiopathic peripheral facial paralysis, is the most common cause of unilateral facial weakness that is not accompanied by any other neurological finding. Although the pathogenesis of Bell palsy is not fully understood, inflammation is thought to play an...
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| Format: | Article |
| Language: | English |
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Van Yuzuncu Yil University, School of Medicine
2021-07-01
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| Series: | Van Tıp Dergisi |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-34341 |
| _version_ | 1827616379146076160 |
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| author | Ülkühan Öztoprak |
| author_facet | Ülkühan Öztoprak |
| author_sort | Ülkühan Öztoprak |
| collection | DOAJ |
| description | INTRODUCTION: Bell's palsy, also known as idiopathic peripheral facial paralysis, is the most common cause of unilateral facial weakness that is not accompanied by any other neurological finding. Although the pathogenesis of Bell palsy is not fully understood, inflammation is thought to play an important role. Neutrophil to lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean mean platelet volume (MPV), are among the markers used to determination of inflammation. The study aimed to investigate the presence of any clues suggesting inflammatory etiology using NLR, PLR, MPV, and red cell distribution width (RDW) in children with Bell's palsy and to determine whether there was any relationship between these markers and the degree of paralysis. METHODS: This retrospective study was conducted between January 2018 and January 2020 with 25 children with Bell's palsy and 25 randomly selected healthy controls. Two groups were compared in terms of neutrophil count, NLR, PLR, MPV, and RDW levels. RESULTS: Mean neutrophil, leukocyte counts, and NLR were statistically significantly higher in patients with Bell Palsy than in the control group (p=0.001, p = 0.016, respectively). However, no significant relationship was found between the NLR elevation and the severity of facial paralysis in the patient group. There was no statistically significant difference between the two groups in terms of the mean of lymphocyte count, PLR, MPV, and RDW values. DISCUSSION AND CONCLUSION: The increase in NLR and neutrophil count in children with Bell palsy supports the inflammatory process thought to be responsible for the etiopathogenesis of this disease. |
| first_indexed | 2024-03-09T09:26:14Z |
| format | Article |
| id | doaj.art-a029e02394004e10b4736e51875836cd |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T09:26:14Z |
| publishDate | 2021-07-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-a029e02394004e10b4736e51875836cd2023-12-02T06:03:42ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512021-07-0128339339910.5505/vtd.2021.34341VTD-34341Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial ParalysisÜlkühan Öztoprak0Department of Pediatric Neurology, University of Health Sciences, Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital, 06080, Ankara, TurkeyINTRODUCTION: Bell's palsy, also known as idiopathic peripheral facial paralysis, is the most common cause of unilateral facial weakness that is not accompanied by any other neurological finding. Although the pathogenesis of Bell palsy is not fully understood, inflammation is thought to play an important role. Neutrophil to lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean mean platelet volume (MPV), are among the markers used to determination of inflammation. The study aimed to investigate the presence of any clues suggesting inflammatory etiology using NLR, PLR, MPV, and red cell distribution width (RDW) in children with Bell's palsy and to determine whether there was any relationship between these markers and the degree of paralysis. METHODS: This retrospective study was conducted between January 2018 and January 2020 with 25 children with Bell's palsy and 25 randomly selected healthy controls. Two groups were compared in terms of neutrophil count, NLR, PLR, MPV, and RDW levels. RESULTS: Mean neutrophil, leukocyte counts, and NLR were statistically significantly higher in patients with Bell Palsy than in the control group (p=0.001, p = 0.016, respectively). However, no significant relationship was found between the NLR elevation and the severity of facial paralysis in the patient group. There was no statistically significant difference between the two groups in terms of the mean of lymphocyte count, PLR, MPV, and RDW values. DISCUSSION AND CONCLUSION: The increase in NLR and neutrophil count in children with Bell palsy supports the inflammatory process thought to be responsible for the etiopathogenesis of this disease.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-34341childrenbell's palsyneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiomean platelet volume |
| spellingShingle | Ülkühan Öztoprak Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial Paralysis Van Tıp Dergisi children bell's palsy neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio mean platelet volume |
| title | Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial Paralysis |
| title_full | Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial Paralysis |
| title_fullStr | Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial Paralysis |
| title_full_unstemmed | Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial Paralysis |
| title_short | Assessment of Hematological Parameters and The Relationship with Paralysis Degree in Children with Idiopathic Peripheral Facial Paralysis |
| title_sort | assessment of hematological parameters and the relationship with paralysis degree in children with idiopathic peripheral facial paralysis |
| topic | children bell's palsy neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio mean platelet volume |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-34341 |
| work_keys_str_mv | AT ulkuhanoztoprak assessmentofhematologicalparametersandtherelationshipwithparalysisdegreeinchildrenwithidiopathicperipheralfacialparalysis |