Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases
Various polyphenolic compounds from plants have been confirmed to have different pharmaceutical functions. The purpose of this study was to evaluate citrus polyphenol (CP) for dental applications. A medium with CP was developed to improve oral wound healing. The CP could be used as a supplemental co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-02-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664615000303 |
| _version_ | 1829504440726454272 |
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| author | Hsiao-Cheng Tsai Yi-Chen Li Tai-Horng Young Min-Huey Chen |
| author_facet | Hsiao-Cheng Tsai Yi-Chen Li Tai-Horng Young Min-Huey Chen |
| author_sort | Hsiao-Cheng Tsai |
| collection | DOAJ |
| description | Various polyphenolic compounds from plants have been confirmed to have different pharmaceutical functions. The purpose of this study was to evaluate citrus polyphenol (CP) for dental applications. A medium with CP was developed to improve oral wound healing. The CP could be used as a supplemental compound in mouthwash for periodontal diseases.
Method: In this study, the metabolic activity and cell toxicity of CP (1%, 0.1%, and 0.01%) for fibroblasts were investigated by MTT and lactate dehydrogenase assays (n = 6). The effect of CP on motility of fibroblast was also evaluated via a wound healing model.
Results: The growth of Hs68 cells on TCPS was greatly increased in the presence of 0.01% CP. In addition, the significant difference (p<0.01) of cell toxicity of fibroblast was observed after 6 days in 0.01% CP medium. Using the wound healing model, it was also found that CP could enhance the migratory ability of fibroblasts.
Conclusion: The results confirm the feasibility of CP be a supplemental compound in mouthwash for treatment of periodontal diseases in dental application to improve wound healing in the mouth. |
| first_indexed | 2024-12-16T10:18:39Z |
| format | Article |
| id | doaj.art-a02c10ce40f245c68494ba19b4e44325 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-16T10:18:39Z |
| publishDate | 2016-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-a02c10ce40f245c68494ba19b4e443252022-12-21T22:35:22ZengElsevierJournal of the Formosan Medical Association0929-66462016-02-01115210010710.1016/j.jfma.2015.01.003Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseasesHsiao-Cheng Tsai0Yi-Chen Li1Tai-Horng Young2Min-Huey Chen3Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan, ROCInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan, ROCInstitute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan, ROCGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan, ROCVarious polyphenolic compounds from plants have been confirmed to have different pharmaceutical functions. The purpose of this study was to evaluate citrus polyphenol (CP) for dental applications. A medium with CP was developed to improve oral wound healing. The CP could be used as a supplemental compound in mouthwash for periodontal diseases. Method: In this study, the metabolic activity and cell toxicity of CP (1%, 0.1%, and 0.01%) for fibroblasts were investigated by MTT and lactate dehydrogenase assays (n = 6). The effect of CP on motility of fibroblast was also evaluated via a wound healing model. Results: The growth of Hs68 cells on TCPS was greatly increased in the presence of 0.01% CP. In addition, the significant difference (p<0.01) of cell toxicity of fibroblast was observed after 6 days in 0.01% CP medium. Using the wound healing model, it was also found that CP could enhance the migratory ability of fibroblasts. Conclusion: The results confirm the feasibility of CP be a supplemental compound in mouthwash for treatment of periodontal diseases in dental application to improve wound healing in the mouth.http://www.sciencedirect.com/science/article/pii/S0929664615000303citrus polyphenolproliferationwound healing |
| spellingShingle | Hsiao-Cheng Tsai Yi-Chen Li Tai-Horng Young Min-Huey Chen Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases Journal of the Formosan Medical Association citrus polyphenol proliferation wound healing |
| title | Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases |
| title_full | Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases |
| title_fullStr | Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases |
| title_full_unstemmed | Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases |
| title_short | Citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases |
| title_sort | citrus polyphenol for oral wound healing in oral ulcers and periodontal diseases |
| topic | citrus polyphenol proliferation wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S0929664615000303 |
| work_keys_str_mv | AT hsiaochengtsai citruspolyphenolfororalwoundhealinginoralulcersandperiodontaldiseases AT yichenli citruspolyphenolfororalwoundhealinginoralulcersandperiodontaldiseases AT taihorngyoung citruspolyphenolfororalwoundhealinginoralulcersandperiodontaldiseases AT minhueychen citruspolyphenolfororalwoundhealinginoralulcersandperiodontaldiseases |