Urine as a Source of Liquid Biopsy for Cancer
Tissue biopsy is the gold standard for diagnosis and morphological and immunohistochemical analyses to characterize cancer. However, tissue biopsy usually requires an invasive procedure, and it can be challenging depending on the condition of the patient and the location of the tumor. Even liquid bi...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/11/2652 |
| _version_ | 1797532339647021056 |
|---|---|
| author | Masanori Oshi Vijayashree Murthy Hideo Takahashi Michelle Huyser Maiko Okano Yoshihisa Tokumaru Omar M. Rashid Ryusei Matsuyama Itaru Endo Kazuaki Takabe |
| author_facet | Masanori Oshi Vijayashree Murthy Hideo Takahashi Michelle Huyser Maiko Okano Yoshihisa Tokumaru Omar M. Rashid Ryusei Matsuyama Itaru Endo Kazuaki Takabe |
| author_sort | Masanori Oshi |
| collection | DOAJ |
| description | Tissue biopsy is the gold standard for diagnosis and morphological and immunohistochemical analyses to characterize cancer. However, tissue biopsy usually requires an invasive procedure, and it can be challenging depending on the condition of the patient and the location of the tumor. Even liquid biopsy analysis of body fluids such as blood, saliva, gastric juice, sweat, tears and cerebrospinal fluid may require invasive procedures to obtain samples. Liquid biopsy can be applied to circulating tumor cells (CTCs) or nucleic acids (NAs) in blood. Recently, urine has gained popularity due to its less invasive sampling, ability to easily repeat samples, and ability to follow tumor evolution in real-time, making it a powerful tool for diagnosis and treatment monitoring in cancer patients. With the development and advancements in extraction methods of urinary substances, urinary NAs have been found to be closely related to carcinogenesis, metastasis, and therapeutic response, not only in urological cancers but also in non-urological cancers. This review mainly highlights the components of urine liquid biopsy and their utility and limitations in oncology, especially in non-urological cancers. |
| first_indexed | 2024-03-10T10:57:46Z |
| format | Article |
| id | doaj.art-a02c4b4ccaaf4a07b18fbdaddc867a6a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:57:46Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a02c4b4ccaaf4a07b18fbdaddc867a6a2023-11-21T21:46:18ZengMDPI AGCancers2072-66942021-05-011311265210.3390/cancers13112652Urine as a Source of Liquid Biopsy for CancerMasanori Oshi0Vijayashree Murthy1Hideo Takahashi2Michelle Huyser3Maiko Okano4Yoshihisa Tokumaru5Omar M. Rashid6Ryusei Matsuyama7Itaru Endo8Kazuaki Takabe9Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USABreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USAHepatopancreatobiliary (HPB), Surgical Oncology, Department of Surgery, Mount Sinai South Nassau, One South Central Avenue, Valley Stream, NY 11580, USABreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Breast Surgery, Fukushima Medical University, Fukushima 960-1295, JapanBreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USAMichael and Dianne Bienes Comprehensive Cancer Center, Department of Surgery, Holy Cross Hospital, Fort Lauderdale, FL 33308, USADepartment of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama 236-0004, JapanDepartment of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama 236-0004, JapanBreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USATissue biopsy is the gold standard for diagnosis and morphological and immunohistochemical analyses to characterize cancer. However, tissue biopsy usually requires an invasive procedure, and it can be challenging depending on the condition of the patient and the location of the tumor. Even liquid biopsy analysis of body fluids such as blood, saliva, gastric juice, sweat, tears and cerebrospinal fluid may require invasive procedures to obtain samples. Liquid biopsy can be applied to circulating tumor cells (CTCs) or nucleic acids (NAs) in blood. Recently, urine has gained popularity due to its less invasive sampling, ability to easily repeat samples, and ability to follow tumor evolution in real-time, making it a powerful tool for diagnosis and treatment monitoring in cancer patients. With the development and advancements in extraction methods of urinary substances, urinary NAs have been found to be closely related to carcinogenesis, metastasis, and therapeutic response, not only in urological cancers but also in non-urological cancers. This review mainly highlights the components of urine liquid biopsy and their utility and limitations in oncology, especially in non-urological cancers.https://www.mdpi.com/2072-6694/13/11/2652liquid biopsyurineurine liquid biopsyDNAmRNAmicroRNA |
| spellingShingle | Masanori Oshi Vijayashree Murthy Hideo Takahashi Michelle Huyser Maiko Okano Yoshihisa Tokumaru Omar M. Rashid Ryusei Matsuyama Itaru Endo Kazuaki Takabe Urine as a Source of Liquid Biopsy for Cancer Cancers liquid biopsy urine urine liquid biopsy DNA mRNA microRNA |
| title | Urine as a Source of Liquid Biopsy for Cancer |
| title_full | Urine as a Source of Liquid Biopsy for Cancer |
| title_fullStr | Urine as a Source of Liquid Biopsy for Cancer |
| title_full_unstemmed | Urine as a Source of Liquid Biopsy for Cancer |
| title_short | Urine as a Source of Liquid Biopsy for Cancer |
| title_sort | urine as a source of liquid biopsy for cancer |
| topic | liquid biopsy urine urine liquid biopsy DNA mRNA microRNA |
| url | https://www.mdpi.com/2072-6694/13/11/2652 |
| work_keys_str_mv | AT masanorioshi urineasasourceofliquidbiopsyforcancer AT vijayashreemurthy urineasasourceofliquidbiopsyforcancer AT hideotakahashi urineasasourceofliquidbiopsyforcancer AT michellehuyser urineasasourceofliquidbiopsyforcancer AT maikookano urineasasourceofliquidbiopsyforcancer AT yoshihisatokumaru urineasasourceofliquidbiopsyforcancer AT omarmrashid urineasasourceofliquidbiopsyforcancer AT ryuseimatsuyama urineasasourceofliquidbiopsyforcancer AT itaruendo urineasasourceofliquidbiopsyforcancer AT kazuakitakabe urineasasourceofliquidbiopsyforcancer |