OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development
TET enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs stably associate with and are post-translationally modified by the nutrient-sensing enzyme OGT, suggesting a connection between metabolism and the epigenome. Here, we show for the first time that mo...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
eLife Sciences Publications Ltd
2018-10-01
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| 丛编: | eLife |
| 主题: | |
| 在线阅读: | https://elifesciences.org/articles/34870 |