Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases?
Objective:Coronavirus disease-2019 (COVID-19) is a disease with respiratory involvement and the virus-induced endothelial dysfunction is pronounced in the clinical course. In COVID-19 patients, to analyze the laboratory findings and the associations may help to better understand the pathophysiology...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-06-01
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| Series: | Bagcilar Medical Bulletin |
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| Online Access: |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/could-asymmetric-dimethylarginine-have-a-role-in-c/52119
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| author | Müfide Arzu Özkarafakılı Zeynep Mine Yalçınkaya Mustafa İlteriş Bardakçı Işıl Kibar Akıllı |
| author_facet | Müfide Arzu Özkarafakılı Zeynep Mine Yalçınkaya Mustafa İlteriş Bardakçı Işıl Kibar Akıllı |
| author_sort | Müfide Arzu Özkarafakılı |
| collection | DOAJ |
| description | Objective:Coronavirus disease-2019 (COVID-19) is a disease with respiratory involvement and the virus-induced endothelial dysfunction is pronounced in the clinical course. In COVID-19 patients, to analyze the laboratory findings and the associations may help to better understand the pathophysiology of this disease.Method:We analyzed the laboratory markers including white blood cell, platelet, mean platelet volume, red cell distribution width (RDW), lactate dehydrogenase, procalcitonin, arterial blood gas values and asymmetric dimethylarginine (ADMA) levels of 83 hospitalized COVID-19 patients with pneumonia. Thirty healthy individuals were enrolled as a control group and their laboratory findings were compared.Results:No significant difference of ADMA levels (median value 225.6 μg/L vs 225.6 μg/L) was noted between COVID-19 patients and the control group (p=0.771). ADMA had an inverse correlation with RDW (r=-0.391, p<0.001). C-reactive protein (CRP) was the significant variable when patients were compared to the healthy group (p=0.002).Conclusion:ADMA levels do not increase at the beginning of COVID-19 clinical course. CRP, as an established inflammation marker, has an imperative role in the clinical spectrum of this coronavirus infection. |
| first_indexed | 2024-04-10T11:59:15Z |
| format | Article |
| id | doaj.art-a03113ee74aa47d18ce88b10430ccf7b |
| institution | Directory Open Access Journal |
| issn | 2547-9431 |
| language | English |
| last_indexed | 2024-04-10T11:59:15Z |
| publishDate | 2022-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Bagcilar Medical Bulletin |
| spelling | doaj.art-a03113ee74aa47d18ce88b10430ccf7b2023-02-15T16:16:40ZengGalenos YayineviBagcilar Medical Bulletin2547-94312022-06-017210210910.4274/BMB.galenos.2022.2022-01-0613049054Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases?Müfide Arzu Özkarafakılı0Zeynep Mine Yalçınkaya1Mustafa İlteriş Bardakçı2Işıl Kibar Akıllı3 University of Health Sciences Turkey, Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Chest Diseases, İstanbul, Turkey University of Health Sciences Turkey, Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Biochemistry, İstanbul, Turkey University of Health Sciences Turkey, Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Chest Diseases, İstanbul, Turkey University of Health Sciences Turkey, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Chest Diseases, İstanbul, Turkey Objective:Coronavirus disease-2019 (COVID-19) is a disease with respiratory involvement and the virus-induced endothelial dysfunction is pronounced in the clinical course. In COVID-19 patients, to analyze the laboratory findings and the associations may help to better understand the pathophysiology of this disease.Method:We analyzed the laboratory markers including white blood cell, platelet, mean platelet volume, red cell distribution width (RDW), lactate dehydrogenase, procalcitonin, arterial blood gas values and asymmetric dimethylarginine (ADMA) levels of 83 hospitalized COVID-19 patients with pneumonia. Thirty healthy individuals were enrolled as a control group and their laboratory findings were compared.Results:No significant difference of ADMA levels (median value 225.6 μg/L vs 225.6 μg/L) was noted between COVID-19 patients and the control group (p=0.771). ADMA had an inverse correlation with RDW (r=-0.391, p<0.001). C-reactive protein (CRP) was the significant variable when patients were compared to the healthy group (p=0.002).Conclusion:ADMA levels do not increase at the beginning of COVID-19 clinical course. CRP, as an established inflammation marker, has an imperative role in the clinical spectrum of this coronavirus infection. http://behmedicalbulletin.org/archives/archive-detail/article-preview/could-asymmetric-dimethylarginine-have-a-role-in-c/52119 admacovid-19infection |
| spellingShingle | Müfide Arzu Özkarafakılı Zeynep Mine Yalçınkaya Mustafa İlteriş Bardakçı Işıl Kibar Akıllı Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases? Bagcilar Medical Bulletin adma covid-19 infection |
| title | Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases? |
| title_full | Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases? |
| title_fullStr | Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases? |
| title_full_unstemmed | Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases? |
| title_short | Could Asymmetric Dimethylarginine Have a Role in COVID-19 Cases? |
| title_sort | could asymmetric dimethylarginine have a role in covid 19 cases |
| topic | adma covid-19 infection |
| url |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/could-asymmetric-dimethylarginine-have-a-role-in-c/52119
|
| work_keys_str_mv | AT mufidearzuozkarafakılı couldasymmetricdimethylargininehavearoleincovid19cases AT zeynepmineyalcınkaya couldasymmetricdimethylargininehavearoleincovid19cases AT mustafailterisbardakcı couldasymmetricdimethylargininehavearoleincovid19cases AT isılkibarakıllı couldasymmetricdimethylargininehavearoleincovid19cases |