The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?
Lung cancer is the leading cause of cancer-related death. Over the past 5–10 years lung cancer outcomes have significantly improved in part due to better treatment options including immunotherapy and molecularly targeted agents. Unfortunately, the majority of lung cancer patients do not enjoy durabl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/1/13 |
| _version_ | 1797543864936955904 |
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| author | Frank Weinberg Robert P. Dickson Deepak Nagrath Nithya Ramnath |
| author_facet | Frank Weinberg Robert P. Dickson Deepak Nagrath Nithya Ramnath |
| author_sort | Frank Weinberg |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer-related death. Over the past 5–10 years lung cancer outcomes have significantly improved in part due to better treatment options including immunotherapy and molecularly targeted agents. Unfortunately, the majority of lung cancer patients do not enjoy durable responses to these new treatments. Seminal research demonstrated the importance of the gut microbiome in dictating responses to immunotherapy in melanoma patients. However, little is known regarding how other sites of microbiota in the human body affect tumorigenesis and treatment responses. The lungs were traditionally thought to be a sterile environment; however, recent research demonstrated that the lung contains its own dynamic microbiota that can influence disease and pathophysiology. Few studies have explored the role of the lung microbiome in lung cancer biology. In this review article, we discuss the links between the lung microbiota and cancer, with particular focus on immune responses, metabolism and strategies to target the lung microbiome for cancer prevention. |
| first_indexed | 2024-03-10T13:51:40Z |
| format | Article |
| id | doaj.art-a0326aa8cad94599912f77ef70ba74ad |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:51:40Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a0326aa8cad94599912f77ef70ba74ad2023-11-21T02:03:41ZengMDPI AGCancers2072-66942020-12-011311310.3390/cancers13010013The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?Frank Weinberg0Robert P. Dickson1Deepak Nagrath2Nithya Ramnath3Department of Internal Medicine, University of Michigan Health System, Internal Medicine, Ann Arbor, MI 48109, USADepartment of Internal Medicine, University of Michigan Health System, Internal Medicine, Ann Arbor, MI 48109, USADepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USADepartment of Internal Medicine, University of Michigan Health System, Internal Medicine, Ann Arbor, MI 48109, USALung cancer is the leading cause of cancer-related death. Over the past 5–10 years lung cancer outcomes have significantly improved in part due to better treatment options including immunotherapy and molecularly targeted agents. Unfortunately, the majority of lung cancer patients do not enjoy durable responses to these new treatments. Seminal research demonstrated the importance of the gut microbiome in dictating responses to immunotherapy in melanoma patients. However, little is known regarding how other sites of microbiota in the human body affect tumorigenesis and treatment responses. The lungs were traditionally thought to be a sterile environment; however, recent research demonstrated that the lung contains its own dynamic microbiota that can influence disease and pathophysiology. Few studies have explored the role of the lung microbiome in lung cancer biology. In this review article, we discuss the links between the lung microbiota and cancer, with particular focus on immune responses, metabolism and strategies to target the lung microbiome for cancer prevention.https://www.mdpi.com/2072-6694/13/1/13lung cancerlung microbiomemetabolismtumor microenvironmentinflammationimmunity |
| spellingShingle | Frank Weinberg Robert P. Dickson Deepak Nagrath Nithya Ramnath The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? Cancers lung cancer lung microbiome metabolism tumor microenvironment inflammation immunity |
| title | The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? |
| title_full | The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? |
| title_fullStr | The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? |
| title_full_unstemmed | The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? |
| title_short | The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? |
| title_sort | lung microbiome a central mediator of host inflammation and metabolism in lung cancer patients |
| topic | lung cancer lung microbiome metabolism tumor microenvironment inflammation immunity |
| url | https://www.mdpi.com/2072-6694/13/1/13 |
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