Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery?
OBJECTIVE: The purpose of this study was to evaluate the effectiveness of contrast-enhanced ultrasound with a second-generation contrast agent in distinguishing between occlusion and pseudo-occlusion of the cervical internal carotid artery, comparing it with that of conventional Doppler ultrasound a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
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| Series: | Clinics |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000100001&lng=en&tlng=en |
| _version_ | 1811228367081439232 |
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| author | Carlos Augusto Pinto Ventura Erasmo Simão da Silva Giovanni Guido Cerri Pedro Puech Leão Adriano Tachibana Maria Cristina Chammas |
| author_facet | Carlos Augusto Pinto Ventura Erasmo Simão da Silva Giovanni Guido Cerri Pedro Puech Leão Adriano Tachibana Maria Cristina Chammas |
| author_sort | Carlos Augusto Pinto Ventura |
| collection | DOAJ |
| description | OBJECTIVE: The purpose of this study was to evaluate the effectiveness of contrast-enhanced ultrasound with a second-generation contrast agent in distinguishing between occlusion and pseudo-occlusion of the cervical internal carotid artery, comparing it with that of conventional Doppler ultrasound and the gold standard, computed tomography angiography. METHOD: Between June 2006 and June 2012, we screened 72 symptomatic vascular surgery outpatients at a public hospital. Among those patients, 78 cervical internal carotid arteries were previously classified as occluded by Doppler ultrasound (without contrast). The patients were examined again with Doppler ultrasound, as well as with contrast-enhanced ultrasound and computed tomography angiography. The diagnosis was based on the presence or absence of flow. RESULTS: Among the 78 cervical internal carotid arteries identified as occluded by Doppler ultrasound, occlusion was confirmed by computed tomography angiography in only 57 (73.1%), compared with 59 (77.5%) for which occlusion was confirmed by contrast-enhanced ultrasound (p>0.5 vs. computed tomography angiography). Comparing contrast-enhanced ultrasound with Doppler ultrasound, we found that the proportion of cervical internal carotid arteries classified as occluded was 24.4% higher when the latter was used (p<0.001). CONCLUSIONS: We conclude that, in making the differential diagnosis between occlusion and pseudo-occlusion of the cervical internal carotid artery, contrast-enhanced ultrasound with a second-generation contrast agent is significantly more effective than conventional Doppler ultrasound and is equally as effective as the gold standard (computed tomography angiography). Our findings suggest that contrast-enhanced ultrasound could replace computed tomography angiography in this regard. |
| first_indexed | 2024-04-12T09:56:31Z |
| format | Article |
| id | doaj.art-a03277b6db2c406fb1b5acd48c4a354a |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T09:56:31Z |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-a03277b6db2c406fb1b5acd48c4a354a2022-12-22T03:37:40ZengElsevier EspañaClinics1807-59321980-53227011610.6061/clinics/2015(01)01S1807-59322015000100001Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery?Carlos Augusto Pinto VenturaErasmo Simão da SilvaGiovanni Guido CerriPedro Puech LeãoAdriano TachibanaMaria Cristina ChammasOBJECTIVE: The purpose of this study was to evaluate the effectiveness of contrast-enhanced ultrasound with a second-generation contrast agent in distinguishing between occlusion and pseudo-occlusion of the cervical internal carotid artery, comparing it with that of conventional Doppler ultrasound and the gold standard, computed tomography angiography. METHOD: Between June 2006 and June 2012, we screened 72 symptomatic vascular surgery outpatients at a public hospital. Among those patients, 78 cervical internal carotid arteries were previously classified as occluded by Doppler ultrasound (without contrast). The patients were examined again with Doppler ultrasound, as well as with contrast-enhanced ultrasound and computed tomography angiography. The diagnosis was based on the presence or absence of flow. RESULTS: Among the 78 cervical internal carotid arteries identified as occluded by Doppler ultrasound, occlusion was confirmed by computed tomography angiography in only 57 (73.1%), compared with 59 (77.5%) for which occlusion was confirmed by contrast-enhanced ultrasound (p>0.5 vs. computed tomography angiography). Comparing contrast-enhanced ultrasound with Doppler ultrasound, we found that the proportion of cervical internal carotid arteries classified as occluded was 24.4% higher when the latter was used (p<0.001). CONCLUSIONS: We conclude that, in making the differential diagnosis between occlusion and pseudo-occlusion of the cervical internal carotid artery, contrast-enhanced ultrasound with a second-generation contrast agent is significantly more effective than conventional Doppler ultrasound and is equally as effective as the gold standard (computed tomography angiography). Our findings suggest that contrast-enhanced ultrasound could replace computed tomography angiography in this regard.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000100001&lng=en&tlng=encarotid arteryinternalarterial occlusive diseasescontrast mediamicrobubblescarotid artery diseases/ultrasonography |
| spellingShingle | Carlos Augusto Pinto Ventura Erasmo Simão da Silva Giovanni Guido Cerri Pedro Puech Leão Adriano Tachibana Maria Cristina Chammas Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery? Clinics carotid artery internal arterial occlusive diseases contrast media microbubbles carotid artery diseases/ultrasonography |
| title | Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery? |
| title_full | Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery? |
| title_fullStr | Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery? |
| title_full_unstemmed | Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery? |
| title_short | Can contrast-enhanced ultrasound with second-generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo-occlusion of the internal carotid artery? |
| title_sort | can contrast enhanced ultrasound with second generation contrast agents replace computed tomography angiography for distinguishing between occlusion and pseudo occlusion of the internal carotid artery |
| topic | carotid artery internal arterial occlusive diseases contrast media microbubbles carotid artery diseases/ultrasonography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000100001&lng=en&tlng=en |
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