The Origin and Evolution of Ribonucleotide Reduction

The Origin and Evolution of Ribonucleotide Reduction

Ribonucleotide reduction is the only pathway for de novo synthesis of deoxyribonucleotides in extant organisms. This chemically demanding reaction, which proceeds via a carbon-centered free radical, is catalyzed by ribonucleotide reductase (RNR). The mechanism has been deemed unlikely to be catalyze...

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Bibliographic Details
Main Authors: Daniel Lundin, Gustav Berggren, Derek T. Logan, Britt-Marie Sjöberg
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Life
Subjects:
ribonucleotide reductase (RNR)
RNA/RNP world
DNA building blocks
protein evolution
redox chemistry
radical chemistry
deoxyribonucleotides
primordial hydrogen atom abstraction
structural phylogenetics
allosteric regulation
Online Access:http://www.mdpi.com/2075-1729/5/1/604

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