Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk
Chronic obstructive pulmonary disease (COPD) is considered a major cause of death worldwide, and various studies have been conducted for its early diagnosis. Our work developed a scoring system by predicting and validating COPD and performed predictive model implementations. Participants who underwe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/11/3181 |
| _version_ | 1797492843071143936 |
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| author | Sang-Jun Lee Sung-Soo Yoon Myeong-Hoon Lee Hye-Jun Kim Yohwan Lim Hyewon Park Sun Jae Park Seogsong Jeong Hyun-Wook Han |
| author_facet | Sang-Jun Lee Sung-Soo Yoon Myeong-Hoon Lee Hye-Jun Kim Yohwan Lim Hyewon Park Sun Jae Park Seogsong Jeong Hyun-Wook Han |
| author_sort | Sang-Jun Lee |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is considered a major cause of death worldwide, and various studies have been conducted for its early diagnosis. Our work developed a scoring system by predicting and validating COPD and performed predictive model implementations. Participants who underwent a health screening between 2017 and 2020 were extracted from the Korea National Health and Nutrition Examination Survey (KNHANES) database. COPD individuals were defined as aged 40 years or older with prebronchodilator forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC < 0.7). The logistic regression model was performed, and the C-index was used for variable selection. Receiver operating characteristic (ROC) curves with area under the curve (AUC) values were generated for evaluation. Age, sex, waist circumference and diastolic blood pressure were used to predict COPD and to develop a COPD score based on a multivariable model. A simplified model for COPD was validated with an AUC value of 0.780 from the ROC curves. In addition, we evaluated the association of the derived score with cardiovascular disease (CVD). COPD scores showed significant performance in COPD prediction. The developed score also showed a good effect on the diagnostic ability for CVD risk. In the future, studies comparing the diagnostic accuracy of the derived scores with standard diagnostic tests are needed. |
| first_indexed | 2024-03-10T01:10:30Z |
| format | Article |
| id | doaj.art-a034879091f64f588c986bb4a355db72 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:10:30Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a034879091f64f588c986bb4a355db722023-11-23T14:18:09ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011111318110.3390/jcm11113181Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease RiskSang-Jun Lee0Sung-Soo Yoon1Myeong-Hoon Lee2Hye-Jun Kim3Yohwan Lim4Hyewon Park5Sun Jae Park6Seogsong Jeong7Hyun-Wook Han8Department of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Informatics, School of Medicine, CHA University, Seongnam 13488, KoreaChronic obstructive pulmonary disease (COPD) is considered a major cause of death worldwide, and various studies have been conducted for its early diagnosis. Our work developed a scoring system by predicting and validating COPD and performed predictive model implementations. Participants who underwent a health screening between 2017 and 2020 were extracted from the Korea National Health and Nutrition Examination Survey (KNHANES) database. COPD individuals were defined as aged 40 years or older with prebronchodilator forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC < 0.7). The logistic regression model was performed, and the C-index was used for variable selection. Receiver operating characteristic (ROC) curves with area under the curve (AUC) values were generated for evaluation. Age, sex, waist circumference and diastolic blood pressure were used to predict COPD and to develop a COPD score based on a multivariable model. A simplified model for COPD was validated with an AUC value of 0.780 from the ROC curves. In addition, we evaluated the association of the derived score with cardiovascular disease (CVD). COPD scores showed significant performance in COPD prediction. The developed score also showed a good effect on the diagnostic ability for CVD risk. In the future, studies comparing the diagnostic accuracy of the derived scores with standard diagnostic tests are needed.https://www.mdpi.com/2077-0383/11/11/3181chronic obstructive pulmonary diseasecardiovascular diseasescore systemself-diagnosis |
| spellingShingle | Sang-Jun Lee Sung-Soo Yoon Myeong-Hoon Lee Hye-Jun Kim Yohwan Lim Hyewon Park Sun Jae Park Seogsong Jeong Hyun-Wook Han Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk Journal of Clinical Medicine chronic obstructive pulmonary disease cardiovascular disease score system self-diagnosis |
| title | Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk |
| title_full | Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk |
| title_fullStr | Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk |
| title_full_unstemmed | Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk |
| title_short | Health-Screening-Based Chronic Obstructive Pulmonary Disease and Its Effect on Cardiovascular Disease Risk |
| title_sort | health screening based chronic obstructive pulmonary disease and its effect on cardiovascular disease risk |
| topic | chronic obstructive pulmonary disease cardiovascular disease score system self-diagnosis |
| url | https://www.mdpi.com/2077-0383/11/11/3181 |
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