Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction

Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction

Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective...

Full description

Bibliographic Details
Main Authors: T. A. Denisyuk, M. V. Pokrovsky, G. A. Lazareva, T. G. Pokrovskaya, M. V. Korokin, O. A. Osipova, A. I. Lazarev, L. N. Sernov, S. A. Demchenko
Format: Article
Language:Russian
Published: Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 2016-02-01
Series:Кубанский научный медицинский вестник
Subjects:
эндотелиальная дисфункция
статины
l-норвалин
эндотоксин
endothelial dysfunction
statins
l-norvalin
endotoxin
Online Access:https://ksma.elpub.ru/jour/article/view/445
Description
Summary:Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective effects, manifested in preventing the proliferation of coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and normalization values of biochemical markers (Total NO, Expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy found no additive effect of drugs.
ISSN:1608-6228
2541-9544

Similar Items