Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction
Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-02-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/445 |
| _version_ | 1826568848559570944 |
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| author | T. A. Denisyuk M. V. Pokrovsky G. A. Lazareva T. G. Pokrovskaya M. V. Korokin O. A. Osipova A. I. Lazarev L. N. Sernov S. A. Demchenko |
| author_facet | T. A. Denisyuk M. V. Pokrovsky G. A. Lazareva T. G. Pokrovskaya M. V. Korokin O. A. Osipova A. I. Lazarev L. N. Sernov S. A. Demchenko |
| author_sort | T. A. Denisyuk |
| collection | DOAJ |
| description | Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective effects, manifested in preventing the proliferation of coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and normalization values of biochemical markers (Total NO, Expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy found no additive effect of drugs. |
| first_indexed | 2024-03-07T21:49:43Z |
| format | Article |
| id | doaj.art-a0349a37d2be434a88ebed974ee9d8c4 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2025-03-14T11:29:58Z |
| publishDate | 2016-02-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-a0349a37d2be434a88ebed974ee9d8c42025-03-02T10:05:26ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-02-0113034445Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunctionT. A. Denisyuk0M. V. Pokrovsky1G. A. Lazareva2T. G. Pokrovskaya3M. V. Korokin4O. A. Osipova5A. I. Lazarev6L. N. Sernov7S. A. Demchenko8SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»FSAEI VPO «BSU»FSAEI VPO «BSU»SEI HPE KSMU of Russian ministry of healthFSAEI VPO «BSU»FSAEI VPO «BSU»Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective effects, manifested in preventing the proliferation of coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and normalization values of biochemical markers (Total NO, Expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy found no additive effect of drugs.https://ksma.elpub.ru/jour/article/view/445эндотелиальная дисфункциястатиныl-норвалинэндотоксинendothelial dysfunctionstatinsl-norvalinendotoxin |
| spellingShingle | T. A. Denisyuk M. V. Pokrovsky G. A. Lazareva T. G. Pokrovskaya M. V. Korokin O. A. Osipova A. I. Lazarev L. N. Sernov S. A. Demchenko Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction Кубанский научный медицинский вестник эндотелиальная дисфункция статины l-норвалин эндотоксин endothelial dysfunction statins l-norvalin endotoxin |
| title | Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction |
| title_full | Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction |
| title_fullStr | Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction |
| title_full_unstemmed | Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction |
| title_short | Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction |
| title_sort | combined use of statins and inhibitors of arginase l norvaline for correcting endotoksin inducing endotelial dysfunction |
| topic | эндотелиальная дисфункция статины l-норвалин эндотоксин endothelial dysfunction statins l-norvalin endotoxin |
| url | https://ksma.elpub.ru/jour/article/view/445 |
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