Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer

Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer

Abstract Background The impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum resistance. We have identified crucial metabolic differences between cisplatin-resistant (CR) and cisplatin-sensitive (CS) NSCLC cells with elevated i...

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Main Authors: Chunjing Wu, Sydney A. Spector, George Theodoropoulos, Dan J. M. Nguyen, Emily Y. Kim, Ashley Garcia, Niramol Savaraj, Diane C. Lim, Ankita Paul, Lynn G. Feun, Michael Bickerdike, Medhi Wangpaichitr
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Cancer & Metabolism
Subjects:
Lung cancer
Kynurenine
Dual IDO1/TDO2 inhibitors
Cisplatin resistance
Immunometabolism
Drug resistance
Online Access:https://doi.org/10.1186/s40170-023-00307-1

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