Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study
Objectives Two-thirds of patients do not harbor lymph node (LN) metastases after neoadjuvant chemoradiotherapy (nCRT). Our aim was to explore under which circumstances a selective lymph node dissection (LND) strategy, which selects patients for LND based on the restaging results after nCRT, has adde...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-10-01
|
| Series: | BMJ Surgery, Interventions, & Health Technologies |
| Online Access: | https://sit.bmj.com/content/2/1/e000027.full |
| _version_ | 1797215244182880256 |
|---|---|
| author | Didi JJM de Gouw Bastiaan R Klarenbeek Camiel Rosman Janneke PC Grutters |
| author_facet | Didi JJM de Gouw Bastiaan R Klarenbeek Camiel Rosman Janneke PC Grutters |
| author_sort | Didi JJM de Gouw |
| collection | DOAJ |
| description | Objectives Two-thirds of patients do not harbor lymph node (LN) metastases after neoadjuvant chemoradiotherapy (nCRT). Our aim was to explore under which circumstances a selective lymph node dissection (LND) strategy, which selects patients for LND based on the restaging results after nCRT, has added value compared with standard LND in esophageal cancer.Design A decision tree with state-transition model was developed. Input data on short-term and long-term consequences were derived from literature. Sensitivity analyses were conducted to assess promising scenarios and uncertainty.Setting Dutch healthcare system.Participants Hypothetical cohort of esophageal cancer patients who have already received nCRT and are scheduled for esophagectomy.Interventions A standard LND cohort was compared with a cohort of patients that received selective LND based on the restaging results after nCRT.Main outcome measures Quality-adjusted life years (QALYs), residual LN metastases and LND-related complications.Results Selective LND could have short-term benefits, that is, a decrease in the number of performed LNDs and LND-related complications. However, this may not outweigh a slight increase in residual LN metastases which negatively impacts QALYs in the long-term. To accomplish equal QALYs as with standard LND, a new surgical strategy should have the same or higher treatment success rate as standard LND, that is, should show equal or less recurrences due to residual LN metastases.Conclusions The reduction in LND-related complications that is accomplished by selecting patients for LND based on restaging results after nCRT seems not to outweigh a QALY loss in the long-term due to residual LN metastases. Despite the short-term advantages of selective LND, this strategy can only match long-term QALYs of standard LND when its success rate equals the success rate of standard LND. |
| first_indexed | 2024-04-24T11:26:59Z |
| format | Article |
| id | doaj.art-a0395ec34c554dc9804ddcedc078c5ce |
| institution | Directory Open Access Journal |
| issn | 2631-4940 |
| language | English |
| last_indexed | 2024-04-24T11:26:59Z |
| publishDate | 2020-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Surgery, Interventions, & Health Technologies |
| spelling | doaj.art-a0395ec34c554dc9804ddcedc078c5ce2024-04-10T14:50:09ZengBMJ Publishing GroupBMJ Surgery, Interventions, & Health Technologies2631-49402020-10-012110.1136/bmjsit-2019-000027Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling studyDidi JJM de Gouw0Bastiaan R Klarenbeek1Camiel Rosman2Janneke PC Grutters3Surgery, Radboudumc, Nijmegen, The NetherlandsSurgery, Radboudumc, Nijmegen, The NetherlandsSurgery, Radboudumc, Nijmegen, The NetherlandsOperating Rooms and Health Evidence, Radboud Institute of Health Sciences, Radboudumc, Nijmegen, The NetherlandsObjectives Two-thirds of patients do not harbor lymph node (LN) metastases after neoadjuvant chemoradiotherapy (nCRT). Our aim was to explore under which circumstances a selective lymph node dissection (LND) strategy, which selects patients for LND based on the restaging results after nCRT, has added value compared with standard LND in esophageal cancer.Design A decision tree with state-transition model was developed. Input data on short-term and long-term consequences were derived from literature. Sensitivity analyses were conducted to assess promising scenarios and uncertainty.Setting Dutch healthcare system.Participants Hypothetical cohort of esophageal cancer patients who have already received nCRT and are scheduled for esophagectomy.Interventions A standard LND cohort was compared with a cohort of patients that received selective LND based on the restaging results after nCRT.Main outcome measures Quality-adjusted life years (QALYs), residual LN metastases and LND-related complications.Results Selective LND could have short-term benefits, that is, a decrease in the number of performed LNDs and LND-related complications. However, this may not outweigh a slight increase in residual LN metastases which negatively impacts QALYs in the long-term. To accomplish equal QALYs as with standard LND, a new surgical strategy should have the same or higher treatment success rate as standard LND, that is, should show equal or less recurrences due to residual LN metastases.Conclusions The reduction in LND-related complications that is accomplished by selecting patients for LND based on restaging results after nCRT seems not to outweigh a QALY loss in the long-term due to residual LN metastases. Despite the short-term advantages of selective LND, this strategy can only match long-term QALYs of standard LND when its success rate equals the success rate of standard LND.https://sit.bmj.com/content/2/1/e000027.full |
| spellingShingle | Didi JJM de Gouw Bastiaan R Klarenbeek Camiel Rosman Janneke PC Grutters Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study BMJ Surgery, Interventions, & Health Technologies |
| title | Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study |
| title_full | Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study |
| title_fullStr | Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study |
| title_full_unstemmed | Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study |
| title_short | Selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy: a modeling study |
| title_sort | selecting esophageal cancer patients for lymphadenectomy after neoadjuvant chemoradiotherapy a modeling study |
| url | https://sit.bmj.com/content/2/1/e000027.full |
| work_keys_str_mv | AT didijjmdegouw selectingesophagealcancerpatientsforlymphadenectomyafterneoadjuvantchemoradiotherapyamodelingstudy AT bastiaanrklarenbeek selectingesophagealcancerpatientsforlymphadenectomyafterneoadjuvantchemoradiotherapyamodelingstudy AT camielrosman selectingesophagealcancerpatientsforlymphadenectomyafterneoadjuvantchemoradiotherapyamodelingstudy AT jannekepcgrutters selectingesophagealcancerpatientsforlymphadenectomyafterneoadjuvantchemoradiotherapyamodelingstudy |