The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood
<i>Background and Objective:</i> Malnutrition is a major complication of inflammatory bowel disease (IBD). Our aim of the study was to examine the effects of Modulen IBD supplementation, which was administered to IBD patients without limiting their daily diet in addition to medical treat...
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MDPI AG
2019-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/10/620 |
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| author | Mehmet Agin Aylin Yucel Meltem Gumus Hasan Ali Yuksekkaya Gokhan Tumgor |
| author_facet | Mehmet Agin Aylin Yucel Meltem Gumus Hasan Ali Yuksekkaya Gokhan Tumgor |
| author_sort | Mehmet Agin |
| collection | DOAJ |
| description | <i>Background and Objective:</i> Malnutrition is a major complication of inflammatory bowel disease (IBD). Our aim of the study was to examine the effects of Modulen IBD supplementation, which was administered to IBD patients without limiting their daily diet in addition to medical treatment, on the clinical, laboratory, anthropometric values, and disease activities of these patients. <i>Materials and Methods:</i> Seventy three children with IBD were evaluated retrospectively. The cases were classified as those who had Crohn disease receiving (CD-M; <i>n</i> = 16) or not receiving Modulen IBD (CD; <i>n</i> = 19) and those who had ulcerative colitis receiving (UC-M; <i>n</i> = 13) or not receiving Modulen IBD (UC; <i>n</i> = 25). Disease activities, laboratory values, remission rates, and anthropometric measurements of the groups were compared. In addition to IBD treatment, Modulen IBD in which half of the daily calorie requirement was provided was given for eight weeks. <i>Results:</i> In the third month of treatment, 14 (88%) patients were in remission in CD-M group and eight (42%) patients were in remission in CD group. The height and weight z scores, which were low at the time of diagnosis, improved in the first week in CD-M group. Inflammatory parameters (UC) were significantly lower in the UC-M group compared to the UC group in first and third months. In the third month, eight (62%) patients in the UC-M group and four (16%) in the UC group were remitted clinically and in terms of laboratory values. <i>Conclusions:</i> TGF-β-rich enteral nutrition support in children with IBD is an easy, effective, and reliable approach. It was shown that TGF-β-rich enteral nutritional supplementation enabled the disease to enter the remission earlier, and contributed to the early recovery of weight and height scores. |
| first_indexed | 2024-03-12T06:03:58Z |
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| last_indexed | 2024-03-12T06:03:58Z |
| publishDate | 2019-09-01 |
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| record_format | Article |
| series | Medicina |
| spelling | doaj.art-a0397f3141124d3aa94c212292865e8a2023-09-03T03:49:42ZengMDPI AGMedicina1010-660X2019-09-01551062010.3390/medicina55100620medicina55100620The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in ChildhoodMehmet Agin0Aylin Yucel1Meltem Gumus2Hasan Ali Yuksekkaya3Gokhan Tumgor4Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cukurova University Medical Faculty, Saricam, 01380 Adana, TurkeyDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Necmettin Erbakan University Medical Faculty, Meram, 42080 Konya, TurkeyDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Necmettin Erbakan University Medical Faculty, Meram, 42080 Konya, TurkeyDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Necmettin Erbakan University Medical Faculty, Meram, 42080 Konya, TurkeyDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Cukurova University Medical Faculty, Saricam, 01380 Adana, Turkey<i>Background and Objective:</i> Malnutrition is a major complication of inflammatory bowel disease (IBD). Our aim of the study was to examine the effects of Modulen IBD supplementation, which was administered to IBD patients without limiting their daily diet in addition to medical treatment, on the clinical, laboratory, anthropometric values, and disease activities of these patients. <i>Materials and Methods:</i> Seventy three children with IBD were evaluated retrospectively. The cases were classified as those who had Crohn disease receiving (CD-M; <i>n</i> = 16) or not receiving Modulen IBD (CD; <i>n</i> = 19) and those who had ulcerative colitis receiving (UC-M; <i>n</i> = 13) or not receiving Modulen IBD (UC; <i>n</i> = 25). Disease activities, laboratory values, remission rates, and anthropometric measurements of the groups were compared. In addition to IBD treatment, Modulen IBD in which half of the daily calorie requirement was provided was given for eight weeks. <i>Results:</i> In the third month of treatment, 14 (88%) patients were in remission in CD-M group and eight (42%) patients were in remission in CD group. The height and weight z scores, which were low at the time of diagnosis, improved in the first week in CD-M group. Inflammatory parameters (UC) were significantly lower in the UC-M group compared to the UC group in first and third months. In the third month, eight (62%) patients in the UC-M group and four (16%) in the UC group were remitted clinically and in terms of laboratory values. <i>Conclusions:</i> TGF-β-rich enteral nutrition support in children with IBD is an easy, effective, and reliable approach. It was shown that TGF-β-rich enteral nutritional supplementation enabled the disease to enter the remission earlier, and contributed to the early recovery of weight and height scores.https://www.mdpi.com/1010-660X/55/10/620pediatricsgrowth retardation in IBDCrohn diseaseulcerative colitismodulen IBD |
| spellingShingle | Mehmet Agin Aylin Yucel Meltem Gumus Hasan Ali Yuksekkaya Gokhan Tumgor The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood Medicina pediatrics growth retardation in IBD Crohn disease ulcerative colitis modulen IBD |
| title | The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood |
| title_full | The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood |
| title_fullStr | The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood |
| title_full_unstemmed | The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood |
| title_short | The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood |
| title_sort | effect of enteral nutrition support rich in tgf β in the treatment of inflammatory bowel disease in childhood |
| topic | pediatrics growth retardation in IBD Crohn disease ulcerative colitis modulen IBD |
| url | https://www.mdpi.com/1010-660X/55/10/620 |
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