Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis
Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to their progenitor characteristics, MSCs hold unique immunomodulatory properties that provide new opportunities in the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11592 |
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| author | Madina Sarsenova Assel Issabekova Saule Abisheva Kristina Rutskaya-Moroshan Vyacheslav Ogay Arman Saparov |
| author_facet | Madina Sarsenova Assel Issabekova Saule Abisheva Kristina Rutskaya-Moroshan Vyacheslav Ogay Arman Saparov |
| author_sort | Madina Sarsenova |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to their progenitor characteristics, MSCs hold unique immunomodulatory properties that provide new opportunities in the treatment of autoimmune diseases, and can serve as a promising tool in stem cell-based therapy. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that deteriorates quality and function of the synovium membrane, resulting in chronic inflammation, pain and progressive cartilage and bone destruction. The mechanism of RA pathogenesis is associated with dysregulation of innate and adaptive immunity. Current conventional treatments by steroid drugs, antirheumatic drugs and biological agents are being applied in clinical practice. However, long-term use of these drugs causes side effects, and some RA patients may acquire resistance to these drugs. In this regard, recently investigated MSC-based therapy is considered as a promising approach in RA treatment. In this study, we review conventional and modern treatment approaches, such as MSC-based therapy through the understanding of the link between MSCs and the innate and adaptive immune systems. Moreover, we discuss recent achievements in preclinical and clinical studies as well as various strategies for the enhancement of MSC immunoregulatory properties. |
| first_indexed | 2024-03-10T06:01:51Z |
| format | Article |
| id | doaj.art-a039e76fc8f845f99656095a86da1705 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:51Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a039e76fc8f845f99656095a86da17052023-11-22T20:54:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211159210.3390/ijms222111592Mesenchymal Stem Cell-Based Therapy for Rheumatoid ArthritisMadina Sarsenova0Assel Issabekova1Saule Abisheva2Kristina Rutskaya-Moroshan3Vyacheslav Ogay4Arman Saparov5Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, KazakhstanLaboratory of Stem Cells, National Center for Biotechnology, Nur-Sultan 010000, KazakhstanDepartment of Family Medicine №1, Astana Medical University, Nur-Sultan 010000, KazakhstanDepartment of Family Medicine №1, Astana Medical University, Nur-Sultan 010000, KazakhstanLaboratory of Stem Cells, National Center for Biotechnology, Nur-Sultan 010000, KazakhstanDepartment of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, KazakhstanMesenchymal stem cells (MSCs) have great potential to differentiate into various types of cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to their progenitor characteristics, MSCs hold unique immunomodulatory properties that provide new opportunities in the treatment of autoimmune diseases, and can serve as a promising tool in stem cell-based therapy. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that deteriorates quality and function of the synovium membrane, resulting in chronic inflammation, pain and progressive cartilage and bone destruction. The mechanism of RA pathogenesis is associated with dysregulation of innate and adaptive immunity. Current conventional treatments by steroid drugs, antirheumatic drugs and biological agents are being applied in clinical practice. However, long-term use of these drugs causes side effects, and some RA patients may acquire resistance to these drugs. In this regard, recently investigated MSC-based therapy is considered as a promising approach in RA treatment. In this study, we review conventional and modern treatment approaches, such as MSC-based therapy through the understanding of the link between MSCs and the innate and adaptive immune systems. Moreover, we discuss recent achievements in preclinical and clinical studies as well as various strategies for the enhancement of MSC immunoregulatory properties.https://www.mdpi.com/1422-0067/22/21/11592mesenchymal stem cellsrheumatoid arthritisinflammationcell therapycell preconditioningimmunomodulation |
| spellingShingle | Madina Sarsenova Assel Issabekova Saule Abisheva Kristina Rutskaya-Moroshan Vyacheslav Ogay Arman Saparov Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis International Journal of Molecular Sciences mesenchymal stem cells rheumatoid arthritis inflammation cell therapy cell preconditioning immunomodulation |
| title | Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis |
| title_full | Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis |
| title_fullStr | Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis |
| title_full_unstemmed | Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis |
| title_short | Mesenchymal Stem Cell-Based Therapy for Rheumatoid Arthritis |
| title_sort | mesenchymal stem cell based therapy for rheumatoid arthritis |
| topic | mesenchymal stem cells rheumatoid arthritis inflammation cell therapy cell preconditioning immunomodulation |
| url | https://www.mdpi.com/1422-0067/22/21/11592 |
| work_keys_str_mv | AT madinasarsenova mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT asselissabekova mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT sauleabisheva mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT kristinarutskayamoroshan mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT vyacheslavogay mesenchymalstemcellbasedtherapyforrheumatoidarthritis AT armansaparov mesenchymalstemcellbasedtherapyforrheumatoidarthritis |