The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?
The energy demand of breast cancers is in part met through the β‐oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes for rapidly proliferating tumor cells. A significant quantity of fatty acids comes from the hydrolys...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13559 |
| _version_ | 1797853466954039296 |
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| author | Makayla M. Bavis Allison M. Nicholas Alexandria J. Tobin Sherri L. Christian Robert J. Brown |
| author_facet | Makayla M. Bavis Allison M. Nicholas Alexandria J. Tobin Sherri L. Christian Robert J. Brown |
| author_sort | Makayla M. Bavis |
| collection | DOAJ |
| description | The energy demand of breast cancers is in part met through the β‐oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes for rapidly proliferating tumor cells. A significant quantity of fatty acids comes from the hydrolysis of lipoprotein triacylglycerols and phospholipids by lipoprotein lipase (LPL). The lipid obtained via LPL in the breast tumor microenvironment may thus promote breast tumor growth and development. In this hypothesis article, we introduce LPL, provide a meta‐analysis of RNAseq data showing that LPL is associated with poor prognosis, and explain how LPL might play a role in breast cancer prognosis over time. |
| first_indexed | 2024-04-09T19:51:05Z |
| format | Article |
| id | doaj.art-a03bc878c771418fa727728ff195c988 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-04-09T19:51:05Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-a03bc878c771418fa727728ff195c9882023-04-03T06:52:58ZengWileyFEBS Open Bio2211-54632023-04-0113458659610.1002/2211-5463.13559The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme?Makayla M. Bavis0Allison M. Nicholas1Alexandria J. Tobin2Sherri L. Christian3Robert J. Brown4Department of Biochemistry Memorial University of Newfoundland St. John's NL CanadaDepartment of Biochemistry Memorial University of Newfoundland St. John's NL CanadaDepartment of Biochemistry Memorial University of Newfoundland St. John's NL CanadaDepartment of Biochemistry Memorial University of Newfoundland St. John's NL CanadaDepartment of Biochemistry Memorial University of Newfoundland St. John's NL CanadaThe energy demand of breast cancers is in part met through the β‐oxidation of exogenous fatty acids. Fatty acids may also be used to aid in cell signaling and toward the construction of new membranes for rapidly proliferating tumor cells. A significant quantity of fatty acids comes from the hydrolysis of lipoprotein triacylglycerols and phospholipids by lipoprotein lipase (LPL). The lipid obtained via LPL in the breast tumor microenvironment may thus promote breast tumor growth and development. In this hypothesis article, we introduce LPL, provide a meta‐analysis of RNAseq data showing that LPL is associated with poor prognosis, and explain how LPL might play a role in breast cancer prognosis over time.https://doi.org/10.1002/2211-5463.13559breast cancerestrogen receptorhuman epidermal growth factor receptor 2lipase maturation factorlipoprotein lipaseprogesterone receptor |
| spellingShingle | Makayla M. Bavis Allison M. Nicholas Alexandria J. Tobin Sherri L. Christian Robert J. Brown The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme? FEBS Open Bio breast cancer estrogen receptor human epidermal growth factor receptor 2 lipase maturation factor lipoprotein lipase progesterone receptor |
| title | The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme? |
| title_full | The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme? |
| title_fullStr | The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme? |
| title_full_unstemmed | The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme? |
| title_short | The breast cancer microenvironment and lipoprotein lipase: Another negative notch for a beneficial enzyme? |
| title_sort | breast cancer microenvironment and lipoprotein lipase another negative notch for a beneficial enzyme |
| topic | breast cancer estrogen receptor human epidermal growth factor receptor 2 lipase maturation factor lipoprotein lipase progesterone receptor |
| url | https://doi.org/10.1002/2211-5463.13559 |
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