White Matter Dissection of the Fetal Brain
Neuroplasticity is a complex process of structural and functional reorganization of brain tissue. In the fetal period, neuroplasticity plays an important role in the emergence and development of white matter tracts. Here, we aimed to study the architecture of normal fetal brains by way of Klingler’s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnana.2020.584266/full |
| _version_ | 1818295165208494080 |
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| author | Bianca Horgos Miruna Mecea Armand Boer Bianca Szabo Andrei Buruiana Florin Stamatian Carmen-Mihaela Mihu Ioan Ştefan Florian Ioan Ştefan Florian Sergiu Susman Sergiu Susman Raluca Pascalau |
| author_facet | Bianca Horgos Miruna Mecea Armand Boer Bianca Szabo Andrei Buruiana Florin Stamatian Carmen-Mihaela Mihu Ioan Ştefan Florian Ioan Ştefan Florian Sergiu Susman Sergiu Susman Raluca Pascalau |
| author_sort | Bianca Horgos |
| collection | DOAJ |
| description | Neuroplasticity is a complex process of structural and functional reorganization of brain tissue. In the fetal period, neuroplasticity plays an important role in the emergence and development of white matter tracts. Here, we aimed to study the architecture of normal fetal brains by way of Klingler’s dissection. Ten normal brains were collected from in utero deceased fetuses aged between 13 and 35 gestational weeks (GW). During this period, we observed modifications in volume, shape, and sulci configuration. Our findings indicate that the major white matter tracts follow four waves of development. The first wave (13 GW) involves the corpus callosum, the fornix, the anterior commissure, and the uncinate fasciculus. In the second one (14 GW), the superior and inferior longitudinal fasciculi and the cingulum could be identified. The third wave (17 GW) concerns the internal capsule and in the fourth wave (20 GW) all the major tracts, including the inferior-occipital fasciculus, were depicted. Our results suggest an earlier development of the white matter tracts than estimated by DTI tractography studies. Correlating anatomical dissection with tractography data is of great interest for further research in the field of fetal brain mapping. |
| first_indexed | 2024-12-13T03:43:18Z |
| format | Article |
| id | doaj.art-a03d022a1ef143b6b59caedd793fbf3c |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-13T03:43:18Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-a03d022a1ef143b6b59caedd793fbf3c2022-12-22T00:00:54ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292020-09-011410.3389/fnana.2020.584266584266White Matter Dissection of the Fetal BrainBianca Horgos0Miruna Mecea1Armand Boer2Bianca Szabo3Andrei Buruiana4Florin Stamatian5Carmen-Mihaela Mihu6Ioan Ştefan Florian7Ioan Ştefan Florian8Sergiu Susman9Sergiu Susman10Raluca Pascalau11Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaFaculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaFaculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Morphological Sciences – Anatomy and Embryology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaFaculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Obstetrics and Gynecology, Imogen Research Center, Cluj-Napoca, RomaniaDepartment of Morphological Sciences – Histology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Neurosurgery, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Neurosurgery, Emergency County Hospital, Cluj-Napoca, RomaniaDepartment of Morphological Sciences – Histology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Pathology and Neuropathology, Imogen Research Center, Cluj-Napoca, RomaniaFaculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, RomaniaNeuroplasticity is a complex process of structural and functional reorganization of brain tissue. In the fetal period, neuroplasticity plays an important role in the emergence and development of white matter tracts. Here, we aimed to study the architecture of normal fetal brains by way of Klingler’s dissection. Ten normal brains were collected from in utero deceased fetuses aged between 13 and 35 gestational weeks (GW). During this period, we observed modifications in volume, shape, and sulci configuration. Our findings indicate that the major white matter tracts follow four waves of development. The first wave (13 GW) involves the corpus callosum, the fornix, the anterior commissure, and the uncinate fasciculus. In the second one (14 GW), the superior and inferior longitudinal fasciculi and the cingulum could be identified. The third wave (17 GW) concerns the internal capsule and in the fourth wave (20 GW) all the major tracts, including the inferior-occipital fasciculus, were depicted. Our results suggest an earlier development of the white matter tracts than estimated by DTI tractography studies. Correlating anatomical dissection with tractography data is of great interest for further research in the field of fetal brain mapping.https://www.frontiersin.org/article/10.3389/fnana.2020.584266/fullfetal brainwhite matter tractsfiber dissectionhuman brain developmentcerebral connectivity |
| spellingShingle | Bianca Horgos Miruna Mecea Armand Boer Bianca Szabo Andrei Buruiana Florin Stamatian Carmen-Mihaela Mihu Ioan Ştefan Florian Ioan Ştefan Florian Sergiu Susman Sergiu Susman Raluca Pascalau White Matter Dissection of the Fetal Brain Frontiers in Neuroanatomy fetal brain white matter tracts fiber dissection human brain development cerebral connectivity |
| title | White Matter Dissection of the Fetal Brain |
| title_full | White Matter Dissection of the Fetal Brain |
| title_fullStr | White Matter Dissection of the Fetal Brain |
| title_full_unstemmed | White Matter Dissection of the Fetal Brain |
| title_short | White Matter Dissection of the Fetal Brain |
| title_sort | white matter dissection of the fetal brain |
| topic | fetal brain white matter tracts fiber dissection human brain development cerebral connectivity |
| url | https://www.frontiersin.org/article/10.3389/fnana.2020.584266/full |
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