Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress
The nucleolus is the site of ribosome biogenesis, a complex process that requires the coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that participate in the maturation of ribosomal RNA (rRNA) and assembly of small and large subunits. Nevertheless, emerging stu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/18/1/140 |
| _version_ | 1811262494629429248 |
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| author | Annapina Russo Giulia Russo |
| author_facet | Annapina Russo Giulia Russo |
| author_sort | Annapina Russo |
| collection | DOAJ |
| description | The nucleolus is the site of ribosome biogenesis, a complex process that requires the coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that participate in the maturation of ribosomal RNA (rRNA) and assembly of small and large subunits. Nevertheless, emerging studies have highlighted the fundamental role of the nucleolus in sensing a variety of cellular stress stimuli that target ribosome biogenesis. This condition is known as nucleolar stress and triggers several response pathways to maintain cell homeostasis, either p53-dependent or p53-independent. The mouse double minute (MDM2)-p53 stress signaling pathways are activated by multiple signals and are among the most important regulators of cellular homeostasis. In this review, we will focus on the role of ribosomal proteins in p53-dependent and p53-independent response to nucleolar stress considering novel identified regulators of these pathways. We describe, in particular, the role of ribosomal protein uL3 (rpL3) in p53-independent nucleolar stress signaling pathways. |
| first_indexed | 2024-04-12T19:27:44Z |
| format | Article |
| id | doaj.art-a03fe8fad9834e628c83ac7d105e4957 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T19:27:44Z |
| publishDate | 2017-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a03fe8fad9834e628c83ac7d105e49572022-12-22T03:19:27ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-01-0118114010.3390/ijms18010140ijms18010140Ribosomal Proteins Control or Bypass p53 during Nucleolar StressAnnapina Russo0Giulia Russo1Department of Pharmacy, University of Naples “Federico II”, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples “Federico II”, 80131 Naples, ItalyThe nucleolus is the site of ribosome biogenesis, a complex process that requires the coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that participate in the maturation of ribosomal RNA (rRNA) and assembly of small and large subunits. Nevertheless, emerging studies have highlighted the fundamental role of the nucleolus in sensing a variety of cellular stress stimuli that target ribosome biogenesis. This condition is known as nucleolar stress and triggers several response pathways to maintain cell homeostasis, either p53-dependent or p53-independent. The mouse double minute (MDM2)-p53 stress signaling pathways are activated by multiple signals and are among the most important regulators of cellular homeostasis. In this review, we will focus on the role of ribosomal proteins in p53-dependent and p53-independent response to nucleolar stress considering novel identified regulators of these pathways. We describe, in particular, the role of ribosomal protein uL3 (rpL3) in p53-independent nucleolar stress signaling pathways.http://www.mdpi.com/1422-0067/18/1/140nucleolar stressp53uL3 (rpL3)apoptosisribosomal proteinsribosomenucleolus |
| spellingShingle | Annapina Russo Giulia Russo Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress International Journal of Molecular Sciences nucleolar stress p53 uL3 (rpL3) apoptosis ribosomal proteins ribosome nucleolus |
| title | Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress |
| title_full | Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress |
| title_fullStr | Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress |
| title_full_unstemmed | Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress |
| title_short | Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress |
| title_sort | ribosomal proteins control or bypass p53 during nucleolar stress |
| topic | nucleolar stress p53 uL3 (rpL3) apoptosis ribosomal proteins ribosome nucleolus |
| url | http://www.mdpi.com/1422-0067/18/1/140 |
| work_keys_str_mv | AT annapinarusso ribosomalproteinscontrolorbypassp53duringnucleolarstress AT giuliarusso ribosomalproteinscontrolorbypassp53duringnucleolarstress |