Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis
Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a result of changes in various cell signaling e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/23/3739 |
| _version_ | 1797463496983576576 |
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| author | Candida Fasano Valentina Grossi Giovanna Forte Cristiano Simone |
| author_facet | Candida Fasano Valentina Grossi Giovanna Forte Cristiano Simone |
| author_sort | Candida Fasano |
| collection | DOAJ |
| description | Colorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a result of changes in various cell signaling effectors. PPIs in signaling and regulatory networks are known to be mediated by short linear motifs (SLiMs), which are conserved contiguous regions of 3–10 amino acids within interacting protein domains. SLiMs are the minimum sequences required for modulating cellular PPI networks. Thus, several in silico approaches have been developed to predict and analyze SLiM-mediated PPIs. In this review, we focus on emerging evidence supporting a crucial role for SLiMs in driver pathways that are disrupted in colorectal cancer (CRC) tumorigenesis and related PPI network alterations. As a result, SLiMs, along with short peptides, are attracting the interest of researchers to devise small molecules amenable to be used as novel anti-CRC targeted therapies. Overall, the characterization of SLiMs mediating crucial PPIs in CRC may foster the development of more specific combined pharmacological approaches. |
| first_indexed | 2024-03-09T17:51:32Z |
| format | Article |
| id | doaj.art-a042274bf41c4e62b5cf4dd0b371580d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:51:32Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a042274bf41c4e62b5cf4dd0b371580d2023-11-24T10:42:57ZengMDPI AGCells2073-44092022-11-011123373910.3390/cells11233739Short Linear Motifs in Colorectal Cancer Interactome and TumorigenesisCandida Fasano0Valentina Grossi1Giovanna Forte2Cristiano Simone3Medical Genetics, National Institute of Gastroenterology-IRCCS “Saverio de Bellis”, Castellana Grotte, 70013 Bari, ItalyMedical Genetics, National Institute of Gastroenterology-IRCCS “Saverio de Bellis”, Castellana Grotte, 70013 Bari, ItalyMedical Genetics, National Institute of Gastroenterology-IRCCS “Saverio de Bellis”, Castellana Grotte, 70013 Bari, ItalyMedical Genetics, National Institute of Gastroenterology-IRCCS “Saverio de Bellis”, Castellana Grotte, 70013 Bari, ItalyColorectal tumorigenesis is driven by alterations in genes and proteins responsible for cancer initiation, progression, and invasion. This multistage process is based on a dense network of protein–protein interactions (PPIs) that become dysregulated as a result of changes in various cell signaling effectors. PPIs in signaling and regulatory networks are known to be mediated by short linear motifs (SLiMs), which are conserved contiguous regions of 3–10 amino acids within interacting protein domains. SLiMs are the minimum sequences required for modulating cellular PPI networks. Thus, several in silico approaches have been developed to predict and analyze SLiM-mediated PPIs. In this review, we focus on emerging evidence supporting a crucial role for SLiMs in driver pathways that are disrupted in colorectal cancer (CRC) tumorigenesis and related PPI network alterations. As a result, SLiMs, along with short peptides, are attracting the interest of researchers to devise small molecules amenable to be used as novel anti-CRC targeted therapies. Overall, the characterization of SLiMs mediating crucial PPIs in CRC may foster the development of more specific combined pharmacological approaches.https://www.mdpi.com/2073-4409/11/23/3739short linear motifsprotein–protein interactionsSLiM-based small moleculescolorectal cancer interactometargeted therapycancer driver protein interactome |
| spellingShingle | Candida Fasano Valentina Grossi Giovanna Forte Cristiano Simone Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis Cells short linear motifs protein–protein interactions SLiM-based small molecules colorectal cancer interactome targeted therapy cancer driver protein interactome |
| title | Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis |
| title_full | Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis |
| title_fullStr | Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis |
| title_full_unstemmed | Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis |
| title_short | Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis |
| title_sort | short linear motifs in colorectal cancer interactome and tumorigenesis |
| topic | short linear motifs protein–protein interactions SLiM-based small molecules colorectal cancer interactome targeted therapy cancer driver protein interactome |
| url | https://www.mdpi.com/2073-4409/11/23/3739 |
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