Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

Fisetin (FST), a potent anticancer phytoconstituent, exhibits poor aqueous solubility and hence poor bioavailability. The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid nanoparticles) as a complex of HPβCD (hydroxy...

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Bibliographic Details
Main Authors: Amrita Kadari, Sagarika Gudem, Hitesh Kulhari, Murali Mohan Bhandi, Roshan M. Borkar, Venkata Ramana Murthy Kolapalli, Ramakrishna Sistla
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
fisetin
hyroxypropyl β-cyclodextrin
inclusion complex
plga nanoparticles
anticancer activity
oral bioavailability
Online Access:http://dx.doi.org/10.1080/10717544.2016.1245366

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